Senior/Research Scientist

3 weeks ago

Slough, United Kingdom SRG Full time

Job Title: Senior/Research Scientist - Mass spec

Contract: 12 months

Location: Slough

Salary: £28.09 - 33.58 PAYE, £38.24 Umbrella

SRG are working with a Global Biopharmaceutical company to help them find a Senior/Research Scientist to join their busy team. This is an exciting opportunity for an individual experienced in HDX-MS to join the Mass Spectrometry team within the Protein Structure and Biophysics Group.

Key Responsibilities will include:

Structural and mechanistic understanding of target and therapeutic molecule interactions are driven by our department using Mass Spectrometry, Cryo-EM, X-ray crystallography, SAXS, NMR and other biophysical techniques.
proven track record in the design and execution of HDX-MS experiments with a contextual understanding of their results alongside other structural data.
manage and prioritise the demands from multiple projects.

Essential Requirements:

PhD or BSc with 5+ years of relevant laboratory-based experience in the design, execution and analysis of HDX-MS experiments for antibody/protein/ligand interactions.
Experienced with Waters data processing software packages (PLGS) and DynamX™.
Practical knowledge Waters HDX-MS system.
Use of structural visualisation tools (PyMOL, Chimera or similar).
Experienced with HDX-MS experiments using NBE and NCE molecules.
Excellent organisational, communication, record keeping and team-working abilities.

Desirable Requirements:

HDX-MS analysis of membrane proteins.
Troubleshooting and maintenance of Waters LC/MS equipment.
Practical ability with Native MS, ion mobility MS, SEC-MS or intact mass LC/MS.
Proven track record of publications related to mass spectrometry in peer reviewed journals.
Appreciation of recombinant protein expression systems and PTMs.
Working knowledge of Thermo Scientific Orbitrap MS systems.

Carbon60, Lorien & SRG - The Impellam Group STEM Portfolio are acting as an Employment Business in relation to this vacancy

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