Senior Scientist
2 weeks ago
Senior Scientist
Location: Slough
Pay Rate:
PAYE:£28.09
Umbrella: £38.24
Contract Length: Initially 12 months
We are seeking an experienced scientist specialising in HDX-MS to join our Mass Spectrometry team within the Protein Structure and Biophysics Group in Slough, UK. The team provides critical project support from the initial adoption into the portfolio through to candidate selection of NBE and NCE therapeutics generated from our discovery platforms. Structural and mechanistic understanding of target and therapeutic molecule interactions are driven by our department using Mass Spectrometry, Cryo-EM, X-ray crystallography, SAXS, NMR, and other biophysical techniques. The successful candidate will have a proven track record in designing and executing HDX-MS experiments, demonstrating contextual understanding of their results alongside other structural data. We require an individual who can quickly integrate into our team, manage and prioritise demands from multiple projects, communicate clearly, and thrive within a highly motivated and multidisciplinary department.
Essential Experience
PhD or BSc with 5+ years of relevant laboratory-based experience in designing, executing, and analysing HDX-MS experiments for antibody/protein/ligand interactions.
Proficient in Waters data processing software packages (PLGS) and DynamX™.
Practical knowledge of Waters HDX-MS system.
Familiarity with structural visualisation tools (PyMOL, Chimera, or similar).
Experience with HDX-MS experiments using NBE and NCE molecules.
Excellent organisational, communication, record-keeping, and team-working abilities.Desirable Experience
HDX-MS analysis of membrane proteins.
Experience troubleshooting and maintaining Waters LC/MS equipment.
Practical ability with Native MS, ion mobility MS, SEC-MS, or intact mass LC/MS.
Proven track record of publications related to mass spectrometry in peer-reviewed journals.
Understanding of recombinant protein expression systems and PTMs.
Working knowledge of Thermo Scientific Orbitrap MS systems.This role offers an exciting opportunity to contribute to cutting-edge research and collaborate within a dynamic team focused on advancing therapeutic discovery and development using state-of-the-art biophysical techniques. If you meet these qualifications and are eager to join a highly motivated and collaborative environment, we encourage you to apply.
Randstad CPE values diversity and promotes equality. No terminology in this advert is intended to discriminate against any of the protected characteristics that fall under the Equality Act 2010. We encourage and welcome applications from all sections of society and are more than happy to discuss reasonable adjustments and/or additional arrangements as required to support your application.
Candidates must be eligible to live and work in the UK.
For the purposes of the Conduct Regulations 2003, when advertising permanent vacancies we are acting as an Employment Agency, and when advertising temporary/contract vacancies we are acting as an Employment Business
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