Protein Engineer
2 weeks ago
Job Description:
We are working in partnership with a start-up biotech firm, supporting them in the growth of their scientific team. They're actively seeking Protein Engineers with Phage Display expertise across varying levels of seniority to join their team. This role is full-time and requires on-site presence for five days a week.
Role Summary:In this role you will be a core part of the Protein Engineering team, working collaboratively with other protein engineers and biochemists to develop soluble high affinity bispecific TCR molecules suitable for later stage clinical development.
Key Deliverables:- Test, screen, and produce soluble TCR-based therapeutics for clinical development using cutting-edge molecular biology techniques, protein engineering methodologies, and structural biology approaches.
- Collaboratively work with the Biology and CMC teams to guide optimization and development of soluble TCRs.
- Design and conduct experimental work aligned with Company priorities and meet scientific timelines, report results succinctly and effectively.
- Drive innovation and continuous improvement within the Protein Engineering team, implementing novel technologies, workflows, and methodologies to enhance productivity and accelerate the drug development process.
Provide oversight of specific elements within a project or projects and supervise other scientists. A PhD in a relevant biological subject alongside some postdoctoral experience and/or experience in the biotech/pharma industry.
Desired but not essential:
- Experience line managing/supervising other scientists.
- Experience working in a matrix environment.
- Direct hands-on laboratory experience in developing high affinity antibodies or soluble TCR molecules using molecular evolution approach (phage display, yeast display etc.)
- Strong proven expertise in molecular biology and protein engineering techniques, including rational design, phage display, library construction, affinity maturation approaches, site-directed mutagenesis, cloning.
- Experience in screening affinity maturation outputs and candidate molecules through techniques such as ELISA, DNA sequence analyses etc.
- Experience in purifying and refolding proteins.
- Experience in analyses of protein affinity and cross-reactivity using SPR/Biacore.
- Working proactively with the team to develop effective strategies prioritized to the needs of the Protein Engineering group; collaborating effectively with other functions.
- Inclusive, collaborative, and thrives in a team environment with a flexible approach to working.
- Strong communication skills with the confidence and judgment to challenge appropriately.
- Demonstrable problem-solving ability, creative thinking, and be proactive in driving the project forwards.
-
Principal Scientist/associate Director
3 weeks ago
London, United Kingdom CK GROUP Full timeCK Group are working in partnership with Avacta to recruit an Principal Scientist/Associate Director - Protein Science to be based at their state of the art facilities in West London on a permanent basis. **About Avacta**: Avacta is a healthcare group developing innovative cancer drugs and powerful in vitro diagnostics to improve human health and well-being....
-
Protein Engineer
2 weeks ago
London, United Kingdom Hlx Life Sciences Full timeWe are working in partnership with a start-up biotech firm, supporting them in the growth of their scientific team. This role is full-time and requires on-site presence for five days a week. Test, screen, and produce soluble TCR-based therapeutics for clinical development using cutting-edge molecular biology techniques, protein engineering methodologies,...
-
Scientist - Protein Expression (CHO/HEK cells)
5 hours ago
London, United Kingdom BioTalent Full timeBiotalent is collaborating with a leading biotechnology company based in London focused on developing biologics to tackle cancer diseases.This is a fantastic opportunity for a scientist with strong background working with CHO/HEK cell lines within R&D. Key Responsibilities:Design and engineer plasmids for the expression of various recombinant proteins,...
-
Scientist - Protein Expression (CHO/HEK cells)
11 hours ago
London Area, United Kingdom BioTalent Full timeBiotalent is collaborating with a leading biotechnology company based in London focused on developing biologics to tackle cancer diseases.This is a fantastic opportunity for a scientist with strong background working with CHO/HEK cell lines within R&D. Key Responsibilities:Design and engineer plasmids for the expression of various recombinant proteins,...
-
Protein Biochemist
7 days ago
Hammersmith, Greater London, United Kingdom Epsilogen Ltd Full timeEpsilogen are seeking a Research Scientist (possibly at Senior Scientist level, depending on experience) with protein biochemistry expertise to join the company at this exciting time in our development. The role will be based at laboratory facilities in West London and will principally involve design and execution of experiments and associated laboratory...
-
Protein Biochemist
7 days ago
Hammersmith, Greater London, United Kingdom Epsilogen Ltd Full timeEpsilogen are seeking a Research Scientist (possibly at Senior Scientist level, depending on experience) with protein biochemistry expertise to join the company at this exciting time in our development. The role will be based at laboratory facilities in West London and will principally involve design and execution of experiments and associated laboratory...
-
Protein Biochemist
5 hours ago
Hammersmith, Greater London, United Kingdom Epsilogen Ltd Full timeJob Description Epsilogen are seeking a Research Scientist (possibly at Senior Scientist level, depending on experience) with protein biochemistry expertise to join the company at this exciting time in our development. The role will be based at laboratory facilities in West London and will principally involve design and execution of experiments and...
-
Experienced Research Engineer
4 days ago
London, United Kingdom Enigma (formerly DS Group) Full timeResearch Scientist - Diffusion - Machine Learning - ML - AI Models - Protein Biology - Python - London - Hybrid Research Engineer (Diffusion) At an innovative company in the intersection of AI and biology, there is an exciting opportunity for a multiple Machine Learning Research Scientists to join an interdisciplinary team of machine learners, protein...
-
Experienced Research Engineer
5 days ago
London, United Kingdom Enigma (formerly DS Group) Full timeResearch Scientist - Diffusion - Machine Learning - ML - AI Models - Protein Biology - Python - London - Hybrid Research Engineer (Diffusion) At an innovative company in the intersection of AI and biology, there is an exciting opportunity for a multiple Machine Learning Research Scientists to join an interdisciplinary team of machine learners, protein...
-
Protein Biochemist
7 days ago
London, United Kingdom Epsilogen Ltd Full timeEpsilogen are seeking a Research Scientist (possibly at Senior Scientist level, depending on experience) with protein biochemistry expertise to join the company at this exciting time in our development. If successful, you will be part of a dynamic and innovative environment. This role requires accurate and precise experimental design and execution in the...
-
Protein Biochemist
7 days ago
Hammersmith, Greater London, United Kingdom Epsilogen Ltd Full timeEpsilogen are seeking a Research Scientist (possibly at Senior Scientist level, depending on experience) with protein biochemistry expertise to join the company at this exciting time in our development. If successful, you will be part of a dynamic and innovative environment. This role requires accurate and precise experimental design and execution in the...
-
Protein Biochemist
7 days ago
Hammersmith, Greater London, United Kingdom Epsilogen Ltd Full timeEpsilogen are seeking a Research Scientist (possibly at Senior Scientist level, depending on experience) with protein biochemistry expertise to join the company at this exciting time in our development. If successful, you will be part of a dynamic and innovative environment. This role requires accurate and precise experimental design and execution in the...
-
Protein Biochemist
5 hours ago
Hammersmith, Greater London, United Kingdom Epsilogen Ltd Full timeJob Description Epsilogen are seeking a Research Scientist (possibly at Senior Scientist level, depending on experience) with protein biochemistry expertise to join the company at this exciting time in our development. If successful, you will be part of a dynamic and innovative environment. This role requires accurate and precise experimental design and...
-
Molecular Data Scientist
3 weeks ago
London, United Kingdom Novo Nordisk AS Full timeThe Position We are searching for a talented Molecular Modelling and/or Data Scientist with strong interest in protein design and machine learning techniques. Your main role will involve enhancing our internal Modelling/AI workflow for data-driven compound design, including the integration of novel ML technologies for protein structure predictions,...
-
PhD Research Scientist
6 days ago
London, United Kingdom InstaDeep Full timeApplied Research Scientist, Molecular Simulation InstaDeep is looking for an Applied Research Scientist to join our expanding team. Applied Research Scientists at InstaDeep develop algorithms and data pipelines focused mainly, but not exclusively, on physics-based methods. As part of the BioAI team, you will be contributing to the development of new...
-
Research Associate
5 days ago
London, United Kingdom Autolus Ltd Full timeVacancy for Research Associate – Binder Discovery We are looking for a motivated Research Associate level scientist to join a multidisciplinary group of researchers within the Binder Discovery Group. This role will focus generation and characterisation of new antibody-based proteins targeting a variety of cancer antigens, TME factors and cell...
-
Molecular Data Scientist
3 weeks ago
London, United Kingdom Novo Nordisk Full timeThe position requires close collaboration with other research scientists in multidisciplinary project teams as well as our data science and machine learning colleagues across the global sites of the Digital Science & Innovation area. Your key responsibilities will entail to: Develop predictive models for biologics design as well as SAR analysis and...
-
Research Associate
5 days ago
London, United Kingdom Autolus Ltd Full timeVacancy for Research Associate – Binder Discovery Location: White City, London, UK Job Summary Role Summary We are looking for a motivated Research Associate level scientist to join a multidisciplinary group of researchers within the Binder Discovery Group. This role will focus generation and characterisation of new antibody-based proteins targeting...
-
Research Associate – Binder Discovery
1 week ago
London, United Kingdom Autolus Limited Full timeRole Summary We are looking for a motivated Research Associate level scientist to join a multidisciplinary group of researchers within the Binder Discovery Group. This role will focus generation and characterisation of new antibody-based proteins targeting a variety of cancer antigens, TME factors and cell engineering targets to develop and improve CAR T...
-
Specialist Analytical Chemist
3 weeks ago
London, United Kingdom Hyper Recruitment Solutions Full timeWe are currently looking for a Senior Analytical Chemist to join a leading developing Gene Therapy company based in London. As the Senior Analytical Chemist you will be responsible for the driving the development of analytical assays for AAV product and process characterisation. This opportunity would suit a Scientist with subject matter expertise in HPLC...