Research Associate
1 month ago
Vacancy for Research Associate – Binder Discovery
We are looking for a motivated Research Associate level scientist to join a multidisciplinary group of researchers within the Binder Discovery Group. This role will focus generation and characterisation of new antibody-based proteins targeting a variety of cancer antigens, TME factors and cell engineering targets to develop and improve CAR T cell therapy.
Successful candidates will need creativity, curiosity and a strong scientific rationale to develop and assess novel antibodies and cell targeting entities as well as help drive projects towards the clinic. A strong background of lab-based research showing independence as well as a solid understanding of immune-oncology therapeutic strategies will be a significant advantage.
This is a unique opportunity to work at the forefront of immunotherapy in rapidly moving and truly multi-disciplinary field.
Molecular biology techniques including PCR, cloning, DNA analysis, modelling of cloning using appropriate software (snapgene etc).
• Characterisation of antibody and CAR T cell performance including;
o Protein analyses techniques; o Cell analysis techniques; Clear and concise documentation of laboratory findings in electronic lab notebook.
• Interpret complex data sets using statistics packages and present conclusions concisely including in presentations to R&D teams and VP/CSO.
• Experience - Prior evidence of substantial laboratory-based experience is a prerequisite.
• Understanding of antibody and CAR structures, and the current state of the art for CAR T cell therapy. (Performance and analysis of large NGS data sets for antibody discovery. (Highly proficient using standard molecular and synthetic biology techniques as well as protein production, purification and analysis methods. (MSc or equivalent in Biology/Biochemistry or related discipline and demonstrable lab experience. Applicants with substantial (3-4 years) relevant industrial experience but not advanced degrees are also welcome to apply. (Familiarity with B cell and T cell biology and immunology (E).
• Understanding of oncology, therapeutic modalities and the advantages/ difficulties facing the field. (Understanding of CAR T cell therapy and antibody-based therapeutics. (Strong skills in molecular cloning including construct and library design, PCR, RT-PCR, DNA assembly and E. coli transformation. (Familiarity with DNA analysis software such as Snapgene. (Familiarity with protein production and purification (E), and assays such as ELISA, flow cytometry, and protein-protein interaction analysis (BIAcore). (Commitment to high quality work.(Ability for creative and critical thinking. (
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