Research Associate – Binder Discovery

3 weeks ago

London, United Kingdom Autolus Limited Full time

Role Summary

We are looking for a motivated Research Associate level scientist to join a multidisciplinary group of researchers within the Binder Discovery Group. This role will focus generation and characterisation of new antibody-based proteins targeting a variety of cancer antigens, TME factors and cell engineering targets to develop and improve CAR T cell therapy. 

Successful candidates will need creativity, curiosity and a strong scientific rationale to develop and assess novel antibodies and cell targeting entities as well as help drive projects towards the clinic. A strong background of lab-based research showing independence as well as a solid understanding of immune-oncology therapeutic strategies will be a significant advantage.

This work will be performed in close collaboration with the wider Autolus R&D teams and successful applicants will work within a wider context of translational and cell manufacturing divisions. Rapid translation to clinical testing is a key motivation of the company. This is a unique opportunity to work at the forefront of immunotherapy in rapidly moving and truly multi-disciplinary field.  

Key Responsibilities
 
•    Antibody generation and protein engineering to target oncology focused antigens. 
•    Mammalian cell culture techniques including aseptic work with multiple different cell lines and culture types. 
•    Molecular biology techniques including PCR, cloning, DNA analysis, modelling of cloning using appropriate software (snapgene etc). 
•    Characterisation of antibody and CAR T cell performance including;
o    Protein analyses techniques; Purification, ELISA, Biacore SPR, SEC chromatography, DSF etc.
o    Cell analysis techniques; Cell culture, flow cytometry, Incucyte, cytokine assays, cytotoxicity assays.  
•    Clear and concise documentation of laboratory findings in electronic lab notebook.
•    Plan and execute experiments with conflicting timelines.
•    Interpret complex data sets using statistics packages and present conclusions concisely including in presentations to R&D teams and VP/CSO. 
•    Any other duties as required following consultation with the post holder.
 

Demonstrated skills and competencies

E – Essential 
P – Preferred

Experience - Prior evidence of substantial laboratory-based experience is a prerequisite. 
•    Knowledge and experience of working with display systems for antibody discovery, including but not limited to phage display (P), as well as yeast and mammalian display (P). 
•    Understanding of antibody and CAR structures, and the current state of the art for CAR T cell therapy. (E)
•    Experience in mammalian cell culture (E), transfection and viral manufacture and transduction. (P)
•    Performance and analysis of large NGS data sets for antibody discovery. (P)
•    Highly proficient using standard molecular and synthetic biology techniques as well as protein production, purification and analysis methods. (E)

Qualifications
MSc or equivalent in Biology/Biochemistry or related discipline and demonstrable lab experience. Applicants with substantial (3-4 years) relevant industrial experience but not advanced degrees are also welcome to apply. (E)

Skills/Specialist knowledge

•    Familiarity with B cell and T cell biology and immunology (E). 
•    Understanding of oncology, therapeutic modalities and the advantages/ difficulties facing the field. (E)
•    Understanding of CAR T cell therapy and antibody-based therapeutics. (E)
•    Strong skills in molecular cloning including construct and library design, PCR, RT-PCR, DNA assembly and E. coli transformation. (E) 
•    Familiarity with DNA analysis software such as Snapgene. (P)
•    Familiarity with protein production and purification (E), and assays such as ELISA, flow cytometry, and protein-protein interaction analysis (BIAcore™). (P)
•    Strong verbal and written communication skills. (E)
•    High attention to detail. (E)
•    Be a self-starter and willing to learn new skills. (E)
•    Commitment to high quality work.(E)
•    Ability for creative and critical thinking. (E)

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