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Research Assistant

3 months ago

Oxford, Oxfordshire, United Kingdom Medical Research Council Full time

Overall Purpose:


We have an open-ended vacancy for a microinjection specialist in the Gene Delivery team at the Mary Lyon Centre (MLC).

The facility currently comprises one modern laboratory with four fully functional microinjection stations. The Gene Delivery group is composed of the laboratory manager and three research assistants.

This dedicated team is responsible for the production of customised mouse models using a range of technologies, including the use of embryonic stem (ES) cells and Crispr/CAS9 genome editing.

The laboratory works in very close collaboration with the ES cell facility, the molecular biology team and animal care staff to guarantee the smooth provision of services.

The Mary Lyon Centre specialises in developing and characterising mouse models of human disease.

Within this context, the Gene Delivery Team has responsibility for generating novel genetically altered mouse strains for the UK biomedical community.

This service is vital to the research of the Mary Lyon Centre, which also offers the national programme Genome Editing Mice for Medicine (GEMM)


The post-holder will report directly to the Gene Delivery laboratory manager and will work closely with all staff at the Mary Lyon Centre.


Main Duties/Key Responsibilities:

Pronuclear and cytoplasmic microinjection of embryos

  • Blastocyst microinjection of embryos
  • Electroporation of embryos
  • Embryo harvesting and culturing of embryos at the relevant developmental stages for genetic modification
  • Embryo vitrification
  • Media and solution preparation
  • Glass pipette preparation
  • Small animal surgery, including the use of anaesthetics for embryo transfers
  • Use of inverted and stereo microscopes
  • General lab duties in keeping the lab clean and well stocked
  • Maintaining an accurate record of all activities
  • Supporting the work of the MLC and other groups within the unit
Full training in all techniques will be offered.

Key responsibilities:

All training will be provided.

Working Relationships:


The post-holder will report to the Gene Delivery laboratory manager and will work closely with staff from the Cellular and Molecular Biology laboratory and the MLC animal care staff to ensure the timely delivery of mouse production service.


Equality & Diversity:


The MRC values the diverse skills and experience of its employees and is committed to achieving equality of treatment for all.

Our objectives are that all individuals shall have equal opportunities for employment and advancement on the basis of their skills, aptitudes and abilities.

The MRC is committed to the engagement and retention of the best possible talent and to creating an environment that encourages excellence in scientific research through good equality and diversity leadership and management.


Corporate/Local Responsibilities & Requirements:

The post-holder must at all times carry out their responsibilities with due regard to the MRC's:

  • Code of Conduct
  • Equality and Diversity policy
  • Health and Safety policy
  • Data Protection and Security policy
***Job descriptions should be reviewed on a regular basis and at the annual appraisal. Any changes should be made and agreed between the post-holder and their manager.


The above lists are not exhaustive and the post-holder is required to undertake such duties as may reasonably be requested within the scope of the post.

All employees are required to act professionally, cooperatively and flexibly in line with the requirements of the post and the MRC.

Person Specification

Education/Qualifications/Training Required:

  • Essential:_
  • HNC or equivalent experience
  • Desirable:_
  • BSc

Previous Work Experience Required:

  • Essential: _
  • An understanding of mammalian biology
  • Some laboratory experience
  • Evidence of working well within a team
  • Proven track record in maintaining accurate and complete records

Knowledge and Experience:

  • Essential:_
  • Basic knowledge of Mendelian genetics
  • Computer literacy

Organisational skills:

  • Essential:_
  • Ability to work independently and prioritise the work
  • Ability to deliver projects on time and work to tight deadlines

Personal skills/Behaviours/Qualities:

  • Essential: _


The post-holder will work within a team and will be expected to foster a good team relations in approaching challenging workloads, so good interpersonal and time-management skills are essential.

The post-holder also needs to able to work independently and be self-motivated to meet group targets.


The MRC is a great place to work and progress your career, be it in scientific research or the support functions.

The MRC is a unique working environment where our researchers are rewarded by world class innovation and collaboration opportunities that the MRC name brings.

The MRC is an excellent place to develop yourself further and a range of training & development opportunities will be available to you, including professional registration with the Science Council.

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