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Biotransformation Development Lead

1 month ago

Slough, United Kingdom UCB Full time

 

Make your mark for patients


We are looking for a talented individual to fill the position of Biotransformation Development Lead to strengthen our global Biotransformation and Enzymology team by contributing to development and drug discovery projects in immunology and neuroscience therapeutic areas. The role can be based in either Braine, Belgium or Slough, UK.

 

What youâll do

  • Planning, performing and interpreting metabolite profiling studies up to and including human ADME studies for regulatory submissions, including MIST evaluation. This will be through working closely with the DMPK and Safety/Tox Representatives.
  • Planning and coordinating outsourced metabolite profiling studies in partnership with Contract Research Organisations.
  • Providing guidance in line with regulatory requirements and applying this to biotransformation strategies.
  • Generating, reporting and communicating metabolic profiles in different biological matrixes from in vitro and/or in vivo studies including active and reactive metabolites by interpretation of mass spectral data.
  • As part of drug design teams, contributing to multi-parameter drug design providing strong ADME input.
  • Acting with a large degree of autonomy whilst providing mentoring support to the biotransformation (BT) team and the wider DMPK department.
  • Representing BT at relevant departmental, managerial and project meetings.
  • Keep up to date with current trends in the biotransformation in development.
  • Providing expert biotransformation knowledge linked to enzymology and DMPK properties to projects at all stages of the value chain including life cycle management.
  • Championing and developing new scientific approaches, technologies and strategies

 

Interested? For this role weâre looking for the following education, experience and skills

  • PhD. (or equivalent) in Biotransformation or DMPK related areas with analytical chemistry experience.
  • Extensive experience in biotransformation and metabolism in the pharmaceutical industry with a particular focus on supporting preclinical and clinical leads.
  • Strong knowledge of international regulatory principles and guidelines regarding human metabolites with particular emphasis on MIST.
  • Experience in working with radiolabeled drugs and drug candidates.
  • Strong background in metabolite identification experience in LC/MS, bioanalytical chemistry and enzymology.
  • Additional skills would include having a drug hunter mentality with expert knowledge in metabolic chemistry and ability to link in-depth knowledge of drug metabolism, physicochemical properties into structural motifs to guide design of NCEs working closely with medicinal chemistry.
  • Experience with in-silico tools, AI data analysis and processing, and drug design platforms.
  • Good understanding of the expression/functionality of the enzymes in various in vitro systems and the ability to apply understanding of drug metabolizing enzymes to elucidate biotransformation pathways and identify metabolites based on experimental data and in silico approaches.
  • Able to work independently in analyzing, interpreting data, writing reports, and managing study flows.
  • Awareness of literature and scientific advances in the field of drug metabolism and disposition.
  • Strong communication and collaborative skills with an ability to facilitate agile decision making in a team working environment.

Are you ready to âgo beyondâ to create value and make your mark for patients? If this sounds like you, then we would love to hear from you 

About us 
UCB is a global biopharmaceutical company, focusing on neurology and immunology. We are around 8,500 people in all four corners of the globe, inspired by patients and driven by science. 

Why work with us? 
At UCB, we donât just complete tasks, we create value. We arenât afraid to push forward, collaborate, and innovate to make our mark for patients. We have a caring, supportive culture where everyone feels included, respected, and has equitable opportunities to do their best work. We âgo beyondâ to create value for our patients, and always with a human focus, whether thatâs on our patients, our employees, or our planet. Working for us, you will discover a place where you can grow, and have the freedom to carve your own career path to achieve your full potential. 

UCB and its subsidiaries encourage diversity and inclusion in the workplace; we are an Equal Opportunity Employer. We do not discriminate on the basis of race/color/religion/sex/national origin/veteran/disability/age/sexual orientation/gender identity.
 
Should you require any adjustments to our process to assist you in demonstrating your strengths and capabilities contact us on EMEA-Reasonable_Accommodation@ucb.com. Please note should your enquiry not relate to adjustments; we will not be able to support you through this channel.

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