Principal Scientist

1 day ago

Oxford, United Kingdom Yellowstone Biosciences Full time

We are looking for a Principal Scientist to join our cell biology team. If you're a motivated individual who excels in teamwork, is eager to grow, and excited about being part of a start-up, we'd love to connect with you.


Role Summary


In this role you will be a core part of the Cell Biology team, designing and troubleshooting assays to examine the binding of TCR bispecific molecules to cells, the activation of T cells and T-cell mediated killing. The applicant will lead programmes, input into strategy and design of the pipeline and mentor junior staff. Ideally, the applicant will have a strong knowledge of immunology and should be confident in a range of cell biology and immunology assays including techniques such as cell culture, flow cytometry, T cell activation and killing assays, cytokine assays, mammalian cell transfection/transduction and microscopy.


Key Deliverables


  • Working proactively with the team to develop effective in vitro testing strategies prioritised to the needs of the biology group; collaborating effectively with other research functions, for example, Protein Engineering and CMC teams to guide optimisation and development of soluble TCRs.
  • Effectively design and conduct experimental work to align with Company priorities and meet scientific timelines, report results succinctly and effectively.
  • Design, conduct, analyse experiments to test safety and efficacy of soluble TCR bispecific molecules generated by the Protein Engineering team.
  • Dissect molecular mechanisms of T cell activation and T cell mediated killing by soluble TCR bispecific molecules, including deploying suitable assays and sourcing required cell lines, human organoids and primary human cells and tissue samples or developing suitable model cell lines expressing genes of interest.
  • Drive innovation and continuous improvement within the Cell Biology team, implementing novel technologies, workflows, and methodologies to enhance productivity and accelerate the drug development process.
  • Support an in vivo testing strategy via an outsourced model as required.
  • Present scientific findings and summary conclusions to your department, project team and the company leadership team.


Experience/Qualifications Required


  • Familiarity with a range of cell and molecular biology techniques, such as flow cytometry analysis, T cell assays, killing assays, cytokine assays, designing and executing recombinant DNA sub-cloning strategies, making lentiviral supernatants, lentiviral transduction.
  • Direct hands-on laboratory experience in testing and developing of biologics including the assessment of the biological impact of their engagement with therapeutic targets.
  • Experience leading projects, overseeing the experimental strategy and co-ordinating the work of other team members.
  • A PhD in a relevant biological subject with or without post-doctoral experience in academia and/or with substantial subsequent biotechnology or pharmaceutical industry experience in R&D teams.
  • Ability to independently lead programmes to advance the company’s goals, review competing priorities and recommend strategies to advance the programme.
  • Working proactively with the team to develop effective strategies prioritised to the needs of the Biology group; collaborating effectively with other functions.
  • Inclusive, collaborative, and thrives in a team environment with a flexible approach to working.
  • Strong communication skills with the confidence and judgement to challenge appropriately.
  • Demonstrable problem-solving ability, creative thinking and be pro-active in driving the project forwards.
  • (Desired but not essential) Experience in the design and oversight of in vivo experiments.

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