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Senior Research Scientist

2 months ago

Oxford, Oxfordshire, United Kingdom Yellowstone Biosciences Full time
{"Role Summary": "As a Principal Scientist at Yellowstone Biosciences, you will be a key member of our Cell Biology team, responsible for designing and troubleshooting assays to examine the binding of TCR bispecific molecules to cells, the activation of T cells, and T-cell mediated killing. You will lead programs, contribute to strategy and design of the pipeline, and mentor junior staff. A strong knowledge of immunology and experience with cell biology and immunology assays, including techniques such as cell culture, flow cytometry, T cell activation and killing assays, cytokine assays, mammalian cell transfection/transduction, and microscopy, are essential for this role.", "Key Responsibilities": "
  • Develop effective in vitro testing strategies prioritized to the needs of the biology group, collaborating effectively with other research functions, such as Protein Engineering and CMC teams, to guide optimization and development of soluble TCRs.
  • Design and conduct experimental work to align with company priorities and meet scientific timelines, reporting results succinctly and effectively.
  • Design, conduct, and analyze experiments to test safety and efficacy of soluble TCR bispecific molecules generated by the Protein Engineering team.
  • Dissect molecular mechanisms of T cell activation and T cell mediated killing by soluble TCR bispecific molecules, including deploying suitable assays and sourcing required cell lines, human organoids, and primary human cells and tissue samples or developing suitable model cell lines expressing genes of interest.
  • Drive innovation and continuous improvement within the Cell Biology team, implementing novel technologies, workflows, and methodologies to enhance productivity and accelerate the drug development process.
  • Support an in vivo testing strategy via an outsourced model as required.
  • Present scientific findings and summary conclusions to your department, project team, and company leadership team.
", "Requirements": "
  • Familiarity with a range of cell and molecular biology techniques, such as flow cytometry analysis, T cell assays, killing assays, cytokine assays, designing and executing recombinant DNA sub-cloning strategies, making lentiviral supernatants, and lentiviral transduction.
  • Direct hands-on laboratory experience in testing and developing biologics, including the assessment of the biological impact of their engagement with therapeutic targets.
  • Experience leading projects, overseeing the experimental strategy, and coordinating the work of other team members.
  • A PhD in a relevant biological subject with or without post-doctoral experience in academia and/or with substantial subsequent biotechnology or pharmaceutical industry experience in R&D teams.
  • Ability to independently lead programs to advance the company's goals, review competing priorities, and recommend strategies to advance the program.
  • Working proactively with the team to develop effective strategies prioritized to the needs of the Biology group, collaborating effectively with other functions.
  • Inclusive, collaborative, and thrives in a team environment with a flexible approach to working.
  • Strong communication skills with the confidence and judgment to challenge appropriately.
  • Demonstrable problem-solving ability, creative thinking, and be pro-active in driving the project forwards.
  • (Desired but not essential) Experience in the design and oversight of in vivo experiments.
", "Company Culture": "At Yellowstone Biosciences, we value a collaborative and inclusive work environment, where our team members can thrive and grow. We are committed to advancing the field of biologics development and are seeking a talented Principal Scientist to join our Cell Biology team.", "What We Offer": "
  • A competitive salary and benefits package.
  • Opportunities for professional growth and development.
  • A dynamic and collaborative work environment.
  • Access to state-of-the-art facilities and equipment.
  • The chance to work on cutting-edge projects and contribute to the advancement of biologics development.
", "How to Apply": "If you are a motivated and experienced Principal Scientist looking for a new challenge, please submit your application, including your resume and a cover letter, to [insert contact information]."}