Senior Scientist- Cell Therapy

4 months ago


Cambridge, United Kingdom Regeneron Pharmaceuticals, Inc Full time

We are seeking a highly skilled and passionate Senior Scientist to support Regeneron Cell Medicine (RCM) mission to bring innovative cell therapy products to patients. This role will be critical to advance TCR- and CAR-based programs, as well as bring new ideas to improve our platforms and future programs.

As a Senior Scientist, a typical day might include:

Leveraging molecular biology techniques to design constructs, clone, and generate lentiviral vectors using proprietary platform technology

Designing and carrying out experimental plans to functionally characterize TCR- and CAR-based T cell products through cell based assays and other relevant procedures to explore and validate novel cell therapy approaches.

Maintaining detailed and timely records of experimental protocols, results, and observations.

Identifying experimental challenges and collaborating with the team to troubleshoot technical issues and propose creative solutions to overcome obstacles.

Stay informed about the latest scientific advancements and applying relevant technologies to improve experimental processes to enhance the efficiency and efficacy of our cell therapy research

This role might be for you if you have:

The ability to work effectively in a team-based research environment, exhibiting leadership in the lab on day-to-day basis

Strong problem-solving skills and capacity to think critically and innovatively

Excellent communication and presentation skills to convey complex scientific information to diverse audiences

Detailed oriented with a commitment to producing high-quality, reliable data

Are excited to support and mentor junior lab members to foster scientific & technical development and ensure experimental excellence

In order to be considered for this role, you must have at least a Ph.D. in Immunology, Cancer Biology, Molecular Biology, or a related field and 0-3 years of relevant experience or a BS/MS and 8-10+ years of relevant experience. Must have hands-on experience on LV-vector construct design, cloning, vector production, and mastery of basic molecular biology techniques is required. Experience with cell-based assays and functional assays measuring T cell activation, cytokine release, proliferation, survival, and tumor cell killing required. Experience with standard readouts of tumor coculture (e.g. MSD, Luminex, ELISA, etc.) is a plus. Knowledge of standard TCR/CAR-T cells culture technique is desired. Experience developing and applying complex flow cytometry panels for the characterization of TCR/CAR-T cells preferred. Experience contributing to writing of patents and/or regulatory documents is advantageous.


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