Senior Scientist
4 weeks ago
We are seeking a highly skilled and passionate Senior Scientist to support Regeneron Cell Medicine's mission to bring innovative cell therapy products to patients.
This role will be critical to advance TCR- and CAR-based programs, as well as bring new ideas to improve our platforms and future programs.
Key Responsibilities:
- Leverage molecular biology techniques to design constructs, clone, and generate lentiviral vectors using proprietary platform technology.
- Design and carry out experimental plans to functionally characterize TCR- and CAR-based T cell products through cell-based assays and other relevant procedures.
- Maintain detailed and timely records of experimental protocols, results, and observations.
- Identify experimental challenges and collaborate with the team to troubleshoot technical issues and propose creative solutions.
- Stay informed about the latest scientific advancements and apply relevant technologies to improve experimental processes.
Requirements:
- Ph.D. in Immunology, Cancer Biology, Molecular Biology, or a related field.
- 0-3 years of relevant experience or a BS/MS and 8-10+ years of relevant experience.
- Hands-on experience with LV-vector construct design, cloning, vector production, and mastery of basic molecular biology techniques.
- Experience with cell-based assays and functional assays measuring T cell activation, cytokine release, proliferation, survival, and tumor cell killing.
Preferred Qualifications:
- Experience with standard readouts of tumor coculture (e.g. MSD, Luminex, ELISA, etc.).
- Knowledge of standard TCR/CAR-T cells culture technique.
- Experience developing and applying complex flow cytometry panels for the characterization of TCR/CAR-T cells.
- Experience contributing to writing of patents and/or regulatory documents.
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