Senior Bioinformatician
2 months ago
We are seeking a Senior Bioinformatician to join the Data Sciences team and work closely with the Discovery Sciences team to advance our internal pipeline. The ideal candidate will be self-motivated and proactive, and demonstrate strong team spirit, enthusiasm, confidence, and dedication. They will be involved end-to-end in shaping the data science needs and solutions across the portfolio to develop better therapies, as part of a highly collaborative and multidisciplinary team of scientists.
- Partner with Engitix scientists and external collaborators to help design experiments, draft and implement analysis plans, and iteratively deliver actionable biological insights and visualizations
- Refine key questions, clearly articulate concepts, needs, and potential solutions, and effectively communicate results to diverse teams
- Establish, test, and improve analysis pipelines, especially for proteomics data
- Identify, ingest, validate, and harmonize key data resources to expand upon and translate insights broadly across modalities, models, and cohorts
- Develop innovative analytical approaches and analysis plans integrating, analyzing, and interpreting high-dimensional multimodal datasets to provide evidence to progress the Engitix portfolio
- Ensure data and analytics integrity through best practices in FAIR data, reproducibility, and documentation
As well as strong communication, organizational, and time management skills, you will have:
- Ph.D. in Bioinformatics, Computational Biology, Biostatistics, or related field with 3+ years of post-degree experience
- Strong programming/scripting skills in R and/or Python, as well as experience working with cloud services (e.g., AWS) and workflow languages (e.g., NextFlow)
- Expertise in quantitative proteomics, including familiarity with mass spectrometry technologies (e.g., LFQ and TMT), hands-on experience with analysis pipelines, and use of key public data resources (e.g., UniProt, STRING).
- Strong hands-on experience of performing analyses in at least one of:-
- Bulk and/or scRNAseq
- Molecular imaging, including spatial proteomics and/or transcriptomics
- Multi-omics and data integration
- Strong foundation in statistics and/or machine learning, including experience with methods such as survival analysis, regression analysis, dimensionality reduction, classification, and clustering
- Desirable: Experience working in a cross-functional team in Oncology or Fibrosis
- Be part of a motivated, dynamic team supporting cutting edge drug discovery
- Constant opportunities to learn, grow, and explore the many opportunities for data science to have impact on drug discovery and development
- State of the art offices at The Westworks, White City London
- Competitive reward package including private medical insurance, bonus, pension, and much more
We are pioneering the way to significantly improve the lives of fibrosis and solid tumour patients and their families. Through our unique understanding of the extra-cellular matrix (ECM), and our world-class technology and approach, we are unlocking insights and enabling the generation of new, advanced therapeutics.
At Engitix, relationships are the foundation of accomplishment.
We are one team working together in service of our mission to significantly improve the lives of fibrosis and solid tumour patients and their families. We care deeply about what we do and the impact we will have. Our dedication to be passionate, committed and respectful is at the heart of how we operate. It’s our DNA.
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