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Laboratory Student Placement in Metabolic Health

1 month ago

Nottingham, United Kingdom Nottingham Trent University Full time

Be part of something bigger.

Doing things differently.

Laboratory Student Placement in Metabolic Health

£22, p.a. pro rata

This is a 40 week fixed term student placement opportunity. 

Please note that this role is only open to NTU students. Applications from those not a current student at NTU will not be considered.

About the Role

This placement will investigate the role of zinc finger homebox-3 in mouse adipose tissue and cultured mouse and / or human (pre-) adipocyte cell lines.

Previous work in a mouse model with a single copy of a coding mutation in ZFHX3 demonstrated lower body size and fat mass with this mutation (PMID: ), this mutation is similar to a GWAS identified human missense mutation in the same exon of a highly conserved region of this gene (PMID: ). The Dumbell lab has been following up on the hypothalamic effects of ZFHX3 to regulate growth axis components in the arcuate nucleus to drive appetite and metabolic phenotype in mice, and the molecular mechanisms driving these changes in neurons.

However evidence exists for a direct effect of ZFHX3 to regulate adiposity in adipose tissue in flies (PMID: ), and studies in other cell types implicate ZFHX3 in JAK/STAT signalling regulation (PMID: ). This project utilises banked tissues from ZFHX3 mutant mice for investigation of mRNA and protein expression changes and phosphorylation status, as well as cell culture knock-down and over-expression experiments. The placement student will gain experience carrying out routine lab work in the active Dumbell research group ), working on cell culture and tissue extraction experiments investigating the role of transcriptional regulator ZFHX3 in adipose tissue / cultured (pre)-adipocytes.

You will gain valuable experience in an active and vibrant research lab, carrying out RNA extractions, cDNA synthesis and qPCR experiments (including analysis), protein extraction and western blotting, and routine cell culture of mouse and human (pre-) adipocytes.

The ideal applicant will already have some laboratory-based experience in one or more of the techniques mentioned, will have excellent communication and record-keeping skills, strong attention to detail, and be confident working independently as part of a busy research team.

For more details, please take a look at the role profile. We'll still consider applications even if you don't meet every single one of the requirements, so don't be put off if you don't match them perfectly. 

About Us

The School of Science and Technology at Nottingham Trent University (NTU) is an exciting multidisciplinary environment for learning, teaching and research, with some of the best facilities in the UK.

We pride ourselves on delivering high-quality teaching and diverse, real-world research. We specialise in biosciences, chemistry, computing and technology, as well as engineering, forensic science, mathematics, physics and sport science. This mix of traditional and modern subjects encourages and inspires future innovators.

Our courses in the Department of Biosciences are research-led, providing students with cutting-edge knowledge and access to high-specification facilities. It is one of the many reasons why our courses are accredited by the Institute of Biomedical Science, the Royal Society of Biology and the Chartered Institute of Ecology and Environment Management.

For any informal queries about the role or the team, please contact  Dr Rebecca Dumbell (Associate Professor of Molecular Neuroendocrinology) at  .

Don't take our word for it...

Here's what our current placement student had to say:

"’I have had such a positive experience on my placement year. I learnt so much about the professional world of work and have gained endless skills that will certainly help me throughout my career and in life. I couldn’t ask for a better team, they have been overly supportive and allowed me to make the most of this opportunity. I am excited to see what’s next "

For more student placement opportunities visit our or InPlace.

Safe and Inclusive

At NTU, we continue to build an inclusive culture that encourages, supports and celebrates the diverse voices and experiences of our students and colleagues. We welcome the unique contributions that you can bring and we encourage people from underrepresented communities and backgrounds to apply to join our team.

This position is only open to post/undergraduate students of Nottingham Trent University where a work placement is required of the course. Applications from overseas students currently studying on a Tier 4 visa will be considered alongside other applications.

Please note that this role is only open to NTU students. Applications from those not a current student at NTU will not be considered.

Please note that unfortunately, this role has been assessed as ineligible for sponsorship under the UK Visas & Immigration points-based immigration system. However, applications are welcome from candidates who do not currently have the right to work in the UK, but who would be eligible to obtain a valid visa via another route. Please consult the Home Office website for further information.

Please note that this role is covered by the Rehabilitation of Offenders Act and successful applicants will be asked to declare any unspent criminal convictions.