Clinical Research Associate

3 weeks ago

Newcastle upon Tyne, United Kingdom Newcastle University Full time

The Role

A Clinical Research Associate position is available based at the Wolfson Childhood Cancer Research Centre and funded by Children’s Cancer North. The position is suitable for a highly motivated and ambitious individual who wishes to develop a clinical academic career in paediatric neurosurgical oncology.

This position will develop novel experimental models of the childhood brain tumour, medulloblastoma, using neurosurgical and laboratory skills. Development of these models – termed fully humanised Organotypic Slice Cultures (OSC) – will provide essential training and pilot data, and the foundation, for a future PhD application.

Working with Dr Rebecca Hill, Dr Melanie Beckett, Dr Louisa Taylor and Prof Steve Clifford, you will be primarily responsible for setting up this proof-of-concept study including; i) model establishment whereby murine cerebellar OSC will act as a scaffold for medulloblastoma tumour-spheroids, ii) characterising and benchmarking novel OSC models against established 2D, 3D, in vivo, and human medulloblastoma datasets, and iii) assessment of therapeutics on OSC models.

You will be integrated into the Paediatric Brain Tumour Research Group (PBTG) at Newcastle University Centre for Cancer and will contribute to other ongoing research studies focused on improving outcomes for children with high-risk medulloblastoma.

This post is full time, fixed term for a period of 12 months.

For informal enquiries contact: Dr Rebecca Hill () or Professor Steve Clifford ()

Find out more about the Newcastle University Centre for Cancer here:

Find out more about the Faculty of Medical Sciences here:

Find out more about our Research Institutes here:

As part of our commitment to career development for research colleagues, the University has developed 3 levels of research role profiles. These profiles set out firstly the generic competences and responsibilities expected of role holders at each level and secondly the general qualifications and experiences needed for entry at a particular level.


Key Accountabilities

• Be responsible for model establishment including optimisation of murine cerebellar slices and tumour spheroid culture techniques
• Establish feasibility of genetic manipulation of OSC models
• Characterise growth dynamics of OSC models with multiphoton imaging and bioluminescence signal tracking
• Multi-omic characterisation and benchmarking of OSC models (e.g. RNAseq and DNA methylation array)
• Assess novel therapeutic combinations arising from ongoing work in the PBTG on OSC models to demonstrate feasibility and relevance
• Interact with other members of the PBTG
• Interact with supervisors, biostatisticians and bioinformaticians to discuss data derived from OSC models and devise appropriate plans for analysis
• Help to prepare data for publication in relevant, high impact factor journals
• Provide guidance to other staff and students, potentially including supervision of undergraduate research project students
• Attend and present your work at laboratory, institute, national and international meetings
• Be prepared to contribute to public engagement events


The Person 

Knowledge, Skills and Experience 

Knowledge
• Expert knowledge of paediatric neurosurgery


Skills
• Knowledge in statistical analyses
• Excellent clinical/neurosurgical skills
• Excellent communication skills
• Basic wet-laboratory skills such as tissue culture

Experience and Achievements
• Experience of laboratory-based research studies
• Involvement in research publications


Other
• Demonstrable drive to succeed and produce work at the highest level
• Clear commitment to a career in paediatric neurosurgery with an interest in clinical/academic research


Attributes and Behaviour

• Ability to work independently and as part of a team
• Willingness to support more junior members of the team
• Willingness to take on extra tasks and support other projects where appropriate
• Capacity for original thought
• Highly organised

Qualifications


• Medical degree
• MRCS
• GMC Registration with license to practice in the UK
• Intercalated BSc or equivalent


Desirable
• Teaching qualification

Newcastle University is a global University where everyone is treated with dignity and respect. As a University of Sanctuary, we aim to provide a welcoming place of safety for all, offering opportunities to people fleeing violence and persecution.

We are committed to being a fully inclusive university which actively recruits, supports and retains colleagues from all sectors of society. We value diversity as well as celebrate, support and thrive on the contributions of all of our employees and the communities they represent. We are proud to be an equal opportunities employer and encourage applications from individuals who can complement our existing teams, we believe that success is built on having teams whose backgrounds and experiences reflect the diversity of our university and student population.

At Newcastle University we hold a silver award in recognition of our good employment practices for the advancement of gender equality. We also hold a Bronze award in recognition of our work towards tackling race inequality in higher education REC. We are a employer and will offer an interview to disabled applicants who meet the essential criteria for the role as part of the offer and interview scheme.

In addition, we are a member of the Euraxess initiative supporting researchers in Europe. 

Requisition ID: 27201


We ensure there's something for everyone and these benefits include: a cycle-to-work schemeshopping discountscompetitive pension schemehealth and wellbeing initiativesactivities and eventsgenerous leavediscounted travelChristmas shutdown

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