Clinical Research Associate
7 days ago
Salary:
£36,962 to £63,152 per annum
Newcastle University is a great place to work, with excellent benefits.
We have a generous holiday package; plus the opportunity to buy more, great pension schemes and a number of health and wellbeing initiatives to support you.
Closing Date: 01 June 2024
The Role
A Clinical Research Associate position is available based at the Wolfson Childhood Cancer Research Centre and funded by Children's Cancer North.
The position is suitable for a highly motivated and ambitious individual who wishes to develop a clinical academic career in paediatric neurosurgical oncology.
Working with Dr Rebecca Hill, Dr Melanie Beckett, Dr Louisa Taylor and Prof Steve Clifford, you will be primarily responsible for setting up this proof-of-concept study including; i) model establishment whereby murine cerebellar OSC will act as a scaffold for medulloblastoma tumour-spheroids, ii) characterising and benchmarking novel OSC models against established 2D, 3D, in vivo, and human medulloblastoma datasets, and iii) assessment of therapeutics on OSC models.
You will be integrated into the Paediatric Brain Tumour Research Group (PBTG) at Newcastle University Centre for Cancer and will contribute to other ongoing research studies focused on improving outcomes for children with high-risk medulloblastoma.
As part of our commitment to career development for research colleagues, the University has developed 3 levels of research role profiles.
These profiles set out firstly the generic competences and responsibilities expected of role holders at each level and secondly the general qualifications and experiences needed for entry at a particular level.
Key Accountabilities- Be responsible for model establishment including optimisation of murine cerebellar slices and tumour spheroid culture techniques
- Establish feasibility of genetic manipulation of OSC models
- Characterise growth dynamics of OSC models with multiphoton imaging and bioluminescence signal tracking
- Multiomic characterisation and benchmarking of OSC models (e.g. RNAseq and DNA methylation array)
- Assess novel therapeutic combinations arising from ongoing work in the PBTG on OSC models to demonstrate feasibility and relevance
- Interact with other members of the PBTG
- Interact with supervisors, biostatisticians and bioinformaticians to discuss data derived from OSC models and devise appropriate plans for analysis
- Help to prepare data for publication in relevant, high impact factor journals
- Provide guidance to other staff and students, potentially including supervision of undergraduate research project students
- Attend and present your work at laboratory, institute, national and international meetings
- Be prepared to contribute to public engagement events
Knowledge, Skills and Experience
Knowledge
- Expert knowledge of paediatric neurosurgery
Skills:
- Knowledge in statistical analyses
- Excellent clinical/neurosurgical skills
- Excellent communication skills
- Basic wetlaboratory skills such as tissue culture
- Experience of laboratorybased research studies
- Involvement in research publications
- Demonstrable drive to succeed and produce work at the highest level
- Clear commitment to a career in paediatric neurosurgery with an interest in clinical/academic research
- Ability to work independently and as part of a team
- Willingness to support more junior members of the team
- Willingness to take on extra tasks and support other projects where appropriate
- Capacity for original thought
- Highly organised
Qualifications:
- Medical degree
- MRCS
- GMC Registration with license to practice in the UK
- Intercalated BSc or equivalent
- Teaching qualification
As a University of Sanctuary, we aim to provide a welcoming place of safety for all, offering opportunities to people fleeing violence and persecution.
At Newcastle University we hold a silver Athena Swan award in recognition of our good employment practices for the advancement of gender equality.
We also hold a Race Equality Charter Bronze award in recognition of our work towards tackling race inequality in higher education REC.
We are a Disability Confident employer and will offer an interview to disabled applicants who meet the essential criteria for the role as part of the offer and interview scheme.
In addition, we are a member of the Euraxess initiative supporting researchers in Europe.Requisition ID: 27201
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