Senior Laboratory Research Scientist

4 weeks ago

London, United Kingdom The Francis Crick Institute Full time

Description

Job title: Senior Laboratory Research Scientist

Reporting to: Katrin Rittinger, Principal Group Leader

Contract term: This is a full-time, fixed term (24 months) position on Crick terms and conditions of employment.

Project summary

We are looking for an enthusiastic and proactive scientist to work with us within our EPSRC-funded Prosperity Partnership collaboration between the Francis Crick Institute and GSK. In this collaboration we are employing covalent fragment screening to simultaneously identify potential new drug targets and small molecules tools. See:

We have already established a high-throughput chemoproteomic platform that enables covalent fragment screening in cells and have identified many novel protein-small molecule interactions which we now want to explore and develop into high quality molecular probes. We are now looking for a Senior Laboratory Research Scientist to join our multi-disciplinary team and work with us on the biochemical and structural characterisation of these newly identified protein-compound interactions to support the rapid generation of tool molecules for disease-relevant protein targets.

The Role

The role will focus on work within the EPSRC- funded Crick-GSK Prosperity Partnership collaboration.

Key responsibilities

These include but are not limited to:

Production of recombinant proteins and subsequent biochemical and structural characterisation of protein-compound complexes

Establishing biochemical and biophysical assays to study the effect of compound engagement on enzymatic activities or protein-protein interactions

Working closely with chemists to explore structure-activity relationships

Collaborating with other lab members on research projects.

Participating and presenting in group meetings, seminars, and scientific meetings.

Writing up findings for publication.

Experience and Competencies

The post holder should embody and demonstrate our core Crick values:

Bold; Open; Collegial

Essential

PhD or M.Sc. in biochemistry or related discipline,

Broad experience in recombinant protein production

Experience in the use of biophysical techniques to study protein-protein and protein-ligand interactions

Excellent technical and problem-solving skills

Excellent organisational and time-management skills

Self-motivated with the ability to work both independently and as part of a team

Strong communication skills to work with diverse scientists across the Prosperity Partnership

Desirable

Experience in the use of eukaryotic systems for recombinant protein expression

Experience in cell culture

Experience in X-ray crystallography

Experience in computational tools to assess protein structure, protein interactions and other properties

About Us

At the Crick, we conduct research at the forefront of biomedical research. We combine rigour with an open and collaborative culture, and are outward-looking, reflecting our status as a partnership of six organisations aiming to pool knowledge, ideas and resources.

We have a wide research portfolio with no divisions or departments, bringing biomedical researchers together with clinicians, physical scientists and applied scientists from our pharmaceutical partners.

We aim to attract the most talented researchers and support them to tackle innovative research questions. Our science technology platforms provide our researchers with access to state-of-the-art technology and expertise.

We provide an excellent learning environment with dedicated education programmes in public engagement with science, education and personal development, and a postdoc training programme that prepares scientists for leadership roles in science.

If you are interested in applying for this role, please apply via our .

All offers of employment are subject to successful security screening and continuous eligibility to work in the United Kingdom.

If you require a visa to work in the UK we will help support your application should you be successful

Find out what benefits the Crick has to offer:

For more information on our great pay and benefits package please click here:

Equality, Diversity & Inclusion:

We welcome applications from all backgrounds. We are committed to providing equal employment opportunities, regardless of ethnicity, nationality, gender, sexual orientation, gender identity, religion, pregnancy, age, disability, or civil partnership, marital or family status. We particularly welcome applications from people who are Minority Ethnic as they are currently underrepresented in the Crick at this level.

Diversity is essential to excellence in scientific endeavour. It increases breadth and perspective, leading to more innovation and creativity. We want the Crick to be a place where everyone feels valued and where diversity is celebrated and seen as part of the foundation for our Institute’s success.

The Crick is committed to creating equality of opportunity and promoting diversity and inclusivity. We all share in the responsibility to actively promote dignity, respect, inclusivity and equal treatment and it is our aim to ensure that these principles are reflected and implemented in all strategies, policies and practices.

Senior Laboratory Research Scientist