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Senior/Laboratory Research Scientist

2 months ago

Central London, United Kingdom The Francis Crick Institute Full time €39,950

The Francis Crick Institute seeks to recruit a cryo-electron microscopy (cryo-EM) scientist to support single-particle and tomography projects.
 
The Senior Laboratory Research Scientist (SLRS) will be appointed to the Structural Biology Science Technology Platform (SB STP), which supports the Crick in the areas of protein science (expression and purification), biophysics, X-ray crystallography, cryo-EM and related areas. The post holder will help provide a world class platform to contribute towards key research in collaboration with the Crick scientific community. This is a lab-based position, responsible for driving forward cryo-EM research by providing scientific support and training in single-particle and tomography technologies.
 
The Crick has a state-of-the-art facility for cryo-electron microscopy and computation and the post will consolidate excellence in these areas. There are excellent facilities for computing and expertise in experimental and computational aspects of cryo-EM being developed through the structural biology platform with support from the Crick Scientific Computing STP.
 
The role of a Senior Laboratory Research Scientist in the Crick is diverse and rewarding. The role covers a wide range of different functions and allows for continuity of lab operations. The role offers support to one or more scientific projects or programmes. Within a Science Technology Platform(STP) - typical activities include:
 
Participating in academic activities, including group meetings and journal clubs, seminars, and scientific meetings.
Training and supervising other lab members in key techniques and protocols, lab operations, and equipment use.
Liaising with Science Operations and attending key quadrant meetings.
Writing risk assessments and SOPs and providing safety guidance to lab members.
 
Support a range of cryo-EM research activities, including sample preparation.
Provide expertise and support in computational image analysis.
Provide training in both experimental and computational aspects of cryo-EM.
 
A higher degree in biological, physical, or engineering sciences; Research experience and expertise in electron microscopy or a related technique.
Specialist knowledge of cryo-electron microscope operation and high-resolution data collection.
Experience in data analysis single particle images and/or tomography data.
Experience with field emission gun microscopes and direct electron detectors.
Proven track record in structural science
Excellent communication skills within a research environment, building highly effective working relationships with scientists and support staff.
PhD in Structural Biology or related areas.
Postdoctoral experience in conducting cutting-edge research in cryo-EM.
Authorship in peer-reviewed publications in internationally recognized scientific journals.
Specialist knowledge of cryo-EM reconstruction software.
Knowledge of scientific computing including Unix shell scripting, Matlab, Python, programming languages.
Flexible working practice.