Senior/Laboratory Research Scientist

3 weeks ago


Central London, United Kingdom The Francis Crick Institute Full time €39,950

SENIOR LABORATORY RESEARCH SCIENTST MANIFEST Research Platform / Flow Cytometry Facility
Reports to : Andy Riddell, Flow Cytometry Facility Lead and MANIFEST Consortium Lead, Prof. Contract term : This is a full-time, fixed term (3 years) position on Crick terms and conditions of employment.
The role will be placed in the Flow Cytometry Facility and will support the MANIFEST research platform led by Prof. Samra Turajlic (Cancer Dynamics Laboratory).
The Research Group & Project
The MANIFEST Research Platform
Immune checkpoint inhibitor therapies which unleash the brakes from immune cells to kill cancer cells, have become standard of care for many cancer subtypes. The success of existing, emerging and future immunotherapies and their routine use in the NHS is dependent on the appropriate tools, data and technology to rationalise their use and manage their side effects. An exciting Senior Laboratory Research Scientist (SLRS) post, specialising in Flow Cytometry, is available within the MANIFEST project (“Multiomic ANalysis of Immunotherapy Features Evidencing Success and Toxicity”), a newly formed ambitious multi-stakeholder consortium involving academic, industry and NHS partners to deliver deep multi-omic profiling for patients with cancer undergoing immunotherapy. The MANIFEST consortium represents a diverse group of UK-wide experts in cancer research and clinical care comprising major NHS trusts, academic institutes and universities, and industry partners. This grant is funded by the UK Office of Life Sciences (OLS) and the Medical Research Council (MRC).
By integrating multiomic data and innovative methodologies, this platform aims to enhance treatment precision and effectiveness.
The successful candidate will join the MANIFEST programme within the Cancer Dynamics research group and will work closely with the Flow Cytometry Science Technology Platform (STP), providing advice, training, and expertise in a range of techniques to analyse human cancer specimens for translational research within the MANIFEST platform. Their time will be spent in the lab, with a primary responsibility for performing multi-colour flow cytometry, cell sorting, and optimiszing and performing single-cell dissociation from different tissue types, including samples that have been fixed for a prolonged time. Whilst the primary responsibility of the role is to support the MANIFEST Flow Cytometry STP, additional responsibilities will include data acquisition, analysis, and general lab organisation/administration.
The post holder will report to the Group Leader, Samra Turajlic, and will interact closely with other laboratory staff from the MANIFEST platform and the Flow Cytometry STP at the Crick, as well as with post-docs, students, scientists, technicians from the lab, and scientific partners of MANIFEST.
Within this role, there will be several opportunities for personal development including access to relevant training and courses, interactions with scientific partners and Key Opinion Leaders across the MANIFEST platform as well as opportunities for training and secondment in different research environments across the UK within the MANIFEST consortium.
Operating as a technical specialist in flow cytometry techniques, including high-dimensional flow cytometry, cell sorting and single-cell dissociation
Actively supporting and training team members to develop their skills and promote collective success
Supporting and contributing to existing projects by effectively and efficiently performing established techniques
Contributing to the day-to-day operations to ensure the laboratory runs as efficiently as possible, including reagent preparation, operation and maintenance of platform equipment, sample accession and preparation, maintenance of safety standards, and general lab organization
Communication and participation in lab work discussions, lab meetings, flow cytometry work meetings, to keep colleagues informed of developments
Striving for continuous performance improvement
Maintaining professional development through attending meetings, seminars, and reading relevant literature
Writing and presenting work to MANIFEST stakeholders as required.
Engaging in relevant MANIFEST programme workflows with academic, NHS and industry partners.
Evidence of extensive experience/skills in flow cytometry and cell sorting
BD FACSAria, Fortessa Symphony)
Flexible working practice
Ability to multi-task and integrate the demands of different activities in parallel to maintaining operation of the laboratory
Computer literacy
Open and interactive approach with line manager, laboratory colleagues, and collaborators
PhD in a relevant discipline
Experience with flow cytometry data analysis software (e.g., Experience in working in an academic environment
At the Crick, we conduct research at the forefront of biomedical research. We combine rigour with an open and collaborative culture, and are outward-looking, reflecting our status as a partnership of six organisations aiming to pool knowledge, ideas and resources.
We have a wide research portfolio with no divisions or departments, bringing biomedical researchers together with clinicians, physical scientists and applied scientists from our pharmaceutical partners.
We aim to attract the most talented researchers and support them to tackle innovative research questions. Our science technology platforms provide our researchers with access to state-of-the-art technology and expertise.
We provide an excellent learning environment with dedicated education programmes in public engagement with science, education and personal development, and a postdoc training programme that prepares scientists for leadership roles in science.
If you are interested in applying for this role, please apply via our website .
All offers of employment are subject to successful security screening and continuous eligibility to work in the United Kingdom.
If you require a visa to work in the UK we will help support your application should you be successful
For more information on our great pay and benefits package please click here:
Equality, Diversity & Inclusion:
We are committed to providing equal employment opportunities, regardless of ethnicity, nationality, gender, sexual orientation, gender identity, religion, pregnancy, age, disability, or civil partnership, marital or family status. Diversity is essential to excellence in scientific endeavour. We want the Crick to be a place where everyone feels valued and where diversity is celebrated and seen as part of the foundation for our Institute’s success.
The Crick is committed to creating equality of opportunity and promoting diversity and inclusivity. We all share in the responsibility to actively promote dignity, respect, inclusivity and equal treatment and it is our aim to ensure that these principles are reflected and implemented in all strategies, policies and practices.
Read more on our website: 



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