Senior Laboratory Research Scientist

1 week ago

London, United Kingdom The Francis Crick Institute Limited Full time

Job title: Senior Laboratory Research Scientist

Reporting to: Foad Rouhani, Group Leader and Jennifer Hay, Director of the Human Biology Facility

Contract term: This is a full-time, permanent position on Crick terms and conditions of employment.

The Role

This is a shared role between the Tissue Regeneration and Clonal Evolution (TRCE) laboratory and the Human Biology Facility (HBF). The major component of the role involves carrying out a substantial research project in the TRCE lab focused on applying cutting-edge gene editing technologies (in vitro and in vivo) to explore mechanisms of tissue regeneration. The successful candidate will work with members of the HBF gene editing team to support relevant projects within the Francis Crick Institute.

The role of a Senior Laboratory Research Scientist at the Crick is diverse and rewarding. Typical activities include:

  1. Undertaking own research project with the TRCE lab, designing, and executing experiments with strategic direction from the group leader.
  2. Providing experimental or technical support to other lab members.
  3. Providing technical expertise for the development, refinement and troubleshooting of relevant or novel methodologies for the TRCE lab and HBF.
  4. Managing gene editing projects and collaborations with other researchers at the Crick.
  5. Participating in academic activities including presentations at lab meetings, Interest Group seminars and external scientific meetings.
  6. Writing up scientific findings for publication and completing revisions of manuscripts.
  7. Assisting with the organisation and management of the laboratory, including maintaining laboratory databases and stocks, ordering of laboratory supplies, monitoring budgets, and routine maintenance of laboratory equipment.
  8. Training and supervising other lab members in key techniques and protocols, lab operations, and equipment use.
  9. Writing risk assessments and Standard Operating Procedures.

Key responsibilities

These include but are not limited to:

  1. Independently devising and leading gene editing projects within the TRCE research program.
  2. Provision of technical and research expertise, as part of the HBF gene editing team, to assist in projects of other research groups.
  3. Establishing new methodologies in the lab.
  4. Maintaining laboratory organisation and supplies.
  5. Training and supporting lab members in standard operating procedures.
  6. Facilitating collaborations within and outside the Crick.
  7. Provision of technical and research support in human stem cell biology including the tissue culture of pluripotent stem cells and organoids.
  8. Human cell engineering encompassing molecular biology and CRISPR/Cas gene editing.
  9. Management of regulatory protocols and research governance for the lab.

Experience and Competencies

  • PhD in cell biology, genetics, genomics or a relevant scientific discipline.
  • Substantial experience in gene editing using iPS/ES cells, primary cells and/or in vivo models.
  • Strong research track-record evidenced by peer-reviewed publications.
  • Strong communication skills to audiences of varied expertise.
  • Proven track record of laboratory managerial and leadership skills.
  • Excellent organizational and time management skills.
  • Experience in facilitating collaborations.
  • Experience in training/mentoring others, including PhD supervision.
  • Scientific curiosity and enthusiasm for cutting-edge discovery science.
  • Expertise in advanced cellular genetic engineering such as CRISPR screens and base and/or prime editing.
  • Experience in human organoid culture techniques.
  • Experience in using animal models and in vivo gene editing.
  • Proficiency in bioinformatics, DNA/RNA sequencing and software for CRISPR/Cas editing strategies.
  • Proven track record of leading independent projects and/or technology development.
  • Ability to develop new scientific research methods and to contribute to research strategy.

About Us

At the Crick, we conduct research at the forefront of biomedical research. We combine rigour with an open and collaborative culture, and are outward-looking, reflecting our status as a partnership of six organisations aiming to pool knowledge, ideas and resources.

We provide an excellent learning environment with dedicated education programmes in public engagement with science, education and personal development, and a postdoc training programme that prepares scientists for leadership roles in science.

If you are interested in applying for this role, please apply via our website.

All offers of employment are subject to successful security screening and continuous eligibility to work in the United Kingdom.

If you require a visa to work in the UK we will help support your application should you be successful.

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