Principal Laboratory Research Scientist

4 weeks ago

Central London, United Kingdom The Francis Crick Institute Full time €52,145

Principal Laboratory Research Scientist Contract term: This is a permanent position on Crick terms and conditions of employment.
Provide senior level support to a Group Leader either in a lab management role or as a technical expert. May have an established scientific reputation.
The role of a Principal Laboratory Research Scientist in the Crick is diverse and rewarding. The role covers a wide range of different functions and allows for continuity of lab operations. The role offers support to one or more scientific projects or programmes. Independently undertaking own research projects, designing, and executing experiments with strategic direction from the group leader.
Providing experimental or technical support to other lab members.
Assisting the Group Leader in writing grant applications and managing research group governance
Participating in academic activities including presentations at lab meetings, Interest Group seminars and external scientific meetings.
Writing up scientific findings for publication and completing revisions.
Organisation and management of the laboratory, including maintaining laboratory databases and stocks, ordering of laboratory supplies, monitoring budgets, and routine maintenance of laboratory equipment.
Writing risk assessments and Standard Operating Procedures.
The Research Group
We are seeking an enthusiastic and ambitious Principal Laboratory Research Scientist to join the Tissue Regeneration and Clonal Evolution (TRCE) laboratory. We are a multi-disciplinary research group with a mission to understand the factors underlying an organ’s regenerative capacity in order to design novel therapeutics to augment biological function.
We aim to elucidate the functional consequences of mutations in these genes and unravel how these molecular perturbations influence hepatocyte clonal biology and the mechanisms of tissue regeneration. Nature Genetics, 2022), organoids and bio-engineered tissues. We are also developing and applying new technologies in single molecule spatial genomics and in vivo gene editing. Our long-term vision is to be able to apply our findings to stimulate regeneration in other non-proliferative tissues, discover the process of organ ageing and to elucidate the molecular steps to cancer.
This is an excellent opportunity for a highly motivated senior scientist to be heavily involved in the start-up of a major laboratory and to provide senior level support in broad scientific management for the research group. Alongside providing technical assistance to other lab members, there will be opportunities and strong encouragement to lead independent projects in areas such in vivo gene editing and liver epigenetics.
Independently devising and leading projects within the TRCE research program
Establishing new methodologies in the lab
Maintaining laboratory organisation and supplies
Training and supporting lab members in standard operating procedures
Provision of technical and research support in the area of human stem cell biology including the tissue culture of pluripotent stem cells and organoids
Human cell engineering encompassing molecular biology and CRISPR/Cas gene editing
Management of regulatory protocols and research governance for the lab
PhD in cell biology, genetics, genomics or a relevant scientific discipline
Substantial post-PhD experience using in vitro and in vivo models
Strong research track-record evidenced by peer-reviewed publications
Proven track record of laboratory managerial and leadership skills
Experience in training/mentoring others, including PhD supervision
Ability to develop new scientific research methods and to contribute to research strategy
Scientific curiosity and enthusiasm for cutting-edge discovery science
Expertise in epigenetics, CRISPR/Cas genetic engineering (knockouts and single-base editing) or metabolism research
Experience in using animal models and in-vivo experiments
Proficiency in bioinformatics, DNA/RNA sequencing and software for CRISPR/Cas editing strategies
Proven track record of leading independent projects and/or technology development
At the Crick, we conduct research at the forefront of biomedical research. We combine rigour with an open and collaborative culture, and are outward-looking, reflecting our status as a partnership of six organisations aiming to pool knowledge, ideas and resources.
We have a wide research portfolio with no divisions or departments, bringing biomedical researchers together with clinicians, physical scientists and applied scientists from our pharmaceutical partners.
We aim to attract the most talented researchers and support them to tackle innovative research questions. Our science technology platforms provide our researchers with access to state-of-the-art technology and expertise.
We provide an excellent learning environment with dedicated education programmes in public engagement with science, education and personal development, and a postdoc training programme that prepares scientists for leadership roles in science.
If you are interested in applying for this role, please apply via our website.
All offers of employment are subject to successful security screening and continuous eligibility to work in the United Kingdom.
If you require a visa to work in the UK we will help support your application should you be successful
For more information on our great pay and benefits package please click here:
Equality, Diversity & Inclusion:
We are committed to providing equal employment opportunities, regardless of ethnicity, nationality, gender, sexual orientation, gender identity, religion, pregnancy, age, disability, or civil partnership, marital or family status. Diversity is essential to excellence in scientific endeavour. We want the Crick to be a place where everyone feels valued and where diversity is celebrated and seen as part of the foundation for our Institute’s success.
The Crick is committed to creating equality of opportunity and promoting diversity and inclusivity. We all share in the responsibility to actively promote dignity, respect, inclusivity and equal treatment and it is our aim to ensure that these principles are reflected and implemented in all strategies, policies and practices.
Read more on our website: 

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