Research Technician
5 days ago
About the role
We are looking for a enthusiastic and experienced research technician to join the Therapeutic vulnerabilities in solid tumors and sarcoma group of Dr Sophie Postel-Vinay and the Chromosomal Translocations group of Prof Terry Rabbitts. The applicant will have the opportunity to join a new group that is being developed in collaboration with an established dynamic team at Gustave Roussy, France. The exciting program is part of a new Fight Kids Cancer grant, and aims at developing and evaluating novel therapeutic approaches to target aggressive transcription factors-driven sarcomas of unmet need of the children and young adult, using notably degrader-based (PROTAC, small molecule or antibody) approaches.
The team has recently launched a program dedicated to desmoplastic small round cell tumour (driven by the EWS-WT1 transcription factor), which has so far mostly focused on molecular characterization (Hénon et al, Cell Rep Med ). This will build the foundations for this new program, which aims at addressing the challenge of targeting transcription factors and developing new therapies for patients, from bench to bedside. The applicant work under the supervision of the PI , in close collaboration with other teams involved in the project at UCL, at The Institute of Cancer Research and Gustave Roussy.
The vast majority (at least the first 2-3 years) of this program will be performed at the Institute of Cancer Research, in Prof Terry Rabbitts group, under his supervision in collaboration with Prof Janet Shipley, using his unique intracellular variable single domain antibodies (iDAb) library.
The job holder will have the opportunity to perform high-throughput screening of antibody-based libraries on proteins of interest followed by protein engineering, to exploit available multi-omics bulk and single cell RNAseq data, proteomic-based data, and eventually perform in vitro functional genomics with cell lines +/- animal models. The focus of the work wil be transcription factor-driven sarcoma (Dr S. Postel-Vinay, Prof J. Shipley), and oncogene-driven acute myeloid leukaemia (Dr R. Sellar), for which approaches will be developed in parallel using Prof Rabbitt’s unique iDAbs technology.
Applications should include a CV and a Cover Letter: In the Cover Letter please evidence the essential and desirable criteria in the Person Specification part of the Job Description. By including a Cover Letter, you can leave blank the “Why you have applied for this role” field in the application form, which is limited in the number of characters it will allow.
The post is graded on UCL grade 6 (salary £35, - £41,) and is funded for 3 years with a possibility of extension.
About you
Successful candidates must have MSc. in Cancer Biology, Haematology or a related discipline (or close to completion) or higher degree.
Willingness to perform in vivo experiments and bioinformatic analyses, and to undergo further training if required and a PhD (or close to completion) with relevant laboratory experience are desirable but not essential.
The candidate should have a solid knowledge of molecular biology, protein chemistry and engineering, Ab structure, genome editing (CRISPR and lentival transfections notably), molecular cloning and cell culture. Experience in high-throughput screening using antibody, phage display, small molecule or DNA encoded libraries is desirable. This role will also benefit those who have experience in imaging (immunofluorescence), flow cytometry and bioinformatics (notably bulk and single-cell RNA-Seq analysis).
What we offer
As well as the exciting opportunities this role presents we also offer some great benefits some of which are below:
41 Days holiday (including 27 days annual leave 8 bank holiday and 6 closure days) Defined benefit career average revalued earnings pension scheme (CARE) Cycle to work scheme and season ticket loan On-Site nursery On-site gym Enhanced maternity, paternity and adoption pay Employee assistance programme: Staff Support Service Discounted medical insurance-
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