Senior Scientist in Translational Pathology, Oncology

Introduction to role: Are you ready to be at the cutting edge of translational science in oncology? Join AstraZeneca's Translational Pathology group within the Oncology R&D Cancer Development Biomarker department as a Senior Scientist Here, you'll have the chance to influence an industry-leading portfolio, from early clinical development of novel therapeutics to post-marketing opportunities for approved targeted therapies. Collaborate across global boundaries and make a real impact in the fight against cancer Accountabilities: In this dynamic role, you'll harness the best available science and technology to develop innovative assays for measuring biomarkers in clinical tissues. Your work will generate crucial disease linkage data, guiding indication selection and identifying targeted patient populations. You'll measure drug target engagement, informing clinical decisions on therapeutically relevant doses and schedules. Dive deep into cancer pathway interactions to guide rational drug combinations and uncover novel mechanisms of resistance by studying tumors at relapse. Are you ready to lead from the bench and drive innovative solutions? Essential Skills/Experience: PhD plus at least 2 years experience in industry/a relevant field. Knowledge in one or more AZ portfolio areas: tumor drivers and resistance, DNA damage response (DDR), immuno‑oncology (IO), epigenetics or antibody drug conjugates (ADC). Skilled in development and validation of biomarker assays. Experience in manual or automated immunohistochemistry (IHC) (brightfield or fluorescence). Experience in microscopy and carrying out digital image analysis. Ability to lead from the bench in problem solving and the development of innovative solutions. Peer‑reviewed publications in the field of translational pathology or cancer biology. Desirable Skills/Experience: Expertise in one or more AZ portfolio areas, including related biology and knowledge of translational approaches to developing therapeutics for cancer. Experience working with human tissues and tissue‑based histopathology methods. Experience of conducting studies for Good Clinical Practice (GCP). Skills in developing multiplexed IHC or in situ hybridization (ISH) assays. Career exposure to the pharmaceutical industry and the drug development process. When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life‑changing medicines. In‑person working gives us the platform we need to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of three days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world. AstraZeneca offers an unparalleled opportunity to work with one of the broadest and deepest Oncology pipelines in the industry. Our commitment to transforming cancer treatment is driven by a science‑based approach and a vision to eliminate cancer as a cause of death. Collaborate with top experts globally, engage with diverse perspectives, and be empowered to innovate and take smart risks. Together, we challenge norms and push boundaries to make a meaningful difference for patients worldwide. Ready to make an impact? Apply now and be part of our mission to shape the future of Oncology Date Posted 04-nov.-2025 Closing Date 18-nov.-2025 Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form. #J-18808-Ljbffr