Research Scientist in Gene Therapy for Norrie Disease

3 days ago


London, Greater London, United Kingdom UCL Eastman Dental Institute Full time

{"About the Role": "We are seeking a highly motivated researcher to work on gene therapy to prevent hearing loss in patients with Norrie disease. This is a rare genetic condition that primarily affects boys who are born blind and from about 12 years of age develop progressively worsening hearing loss. The post holder will evaluate NDP gene augmentation via a viral construct, and test its effectiveness in mouse models of Norrie disease. The goal is to prevent death of the sensory hair cells in the cochlea of the inner ear and hearing loss, and restore retinal vascular barrier function. The post would suit a postdoctoral researcher with a strong background and practical experience in AAV therapies and interest in degenerative disease and therapeutic development.", "Key Responsibilities": "- Evaluate NDP gene augmentation via a viral construct- Test the effectiveness of the gene therapy in mouse models of Norrie disease- Investigate whether the gene therapy prevents death of the sensory hair cells in the cochlea of the inner ear and hearing loss- Restore retinal vascular barrier function- Design NDP viral constructs for clinical Norrie gene therapy", "Requirements": "- PhD (or about to be awarded) in a relevant area- BSc/MSc in a related life science subject (genetics/stem cell biology/developmental biology)- Proven research aptitude and laboratory experience- Experience in AAV gene therapy- Working knowledge of the murine animal model, histology and microscopy", "What We Offer": "- Competitive salary- 41 Days holiday (including 27 days annual leave, 8 bank holiday and 6 closure days)- Defined benefit career average revalued earnings pension scheme (CARE)- Cycle to work scheme and season ticket loan-On-Site nursery-On-site gym- Enhanced maternity, paternity and adoption pay- Employee assistance programme: Staff Support Service- Discounted medical insurance"}



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