Collaborate with Genomics Experts to Unlock Model Biology

1 month ago


Swindon, Swindon, United Kingdom NERC - the Natural Environment Research Council Full time

The Natural Environment Research Council (NERC) invites researchers to collaborate with the functional genomics screening laboratory on projects using complex human in vitro models for CRISPR screening.

As a researcher, you will have the opportunity to work with the FGSL on projects that aim to better understand model biology and enable target identification.

You must be eligible for funding from a reputable organization, such as the MRC.

Applications from UK-based industry parties may also be considered, but please note that cost will be considered when assessing feasibility.

Who Can Apply

To be eligible, you must be a researcher who can demonstrate eligibility for funding from a reputable organization.

Team applications are permitted, and space permitting, applications from UK-based small and medium-sized enterprises and industry parties will also be considered.

Please ensure you do not need to be funded by the MRC to apply.

What We're Looking ForScope

In this collaboration, you will work with the FGSL to define the purpose of the screen and desired outcomes.

The screens will be carried out by scientists employed at the Milner Therapeutics Institute (MTI), but all screens will be run as collaborations to ensure the best possible outcome and data.

You will not need a CRISPR library, as provision has been made for library access through a collaboration with AstraZeneca and the MTI.

However, for small and medium-sized enterprises and industry, we recommend providing your own library to avoid any conflict of interest.

Duration

The duration of the project will be decided on a case-by-case basis, depending on factors such as the model, its expansion capacity, and the size of the proposed screen.

All projects will be highly collaborative, and input from the proposing lead applicant will be key to understanding the model, screen of interest, and likely endpoint assays.

Biological replicates are not routinely used, but exceptions would be for primary immune cell screens where two to three different donors would be needed to assess the impact of donor variability on screen outcome.

Where screens are large, we recommend running the initial screen in a model derived from one patient and then validating hits in models from three or more different patients.

Funding Available

All screens will be run by scientists employed by the MTI, and costs for this will be borne by the MTI and AstraZeneca.

Financial support for screens (consumables) is available either from AstraZeneca or a screening access fund provided by the MRC.

How to Apply

To apply, you must complete an application form through the NERC website, where you can request to join 'Connect: Health Tech'.

Please include details about the in vitro model, desired screen, and endpoint assay.

For more information, please visit the guidance for applicants and frequently asked questions under 'Resources'.

Additional Information

Please provide additional information beyond the scientific rationale in the application form, including information about your model's scalability, gene editing feasibility, and assay controls available.

This will enable the Joint Steering Committee to make an informed decision regarding the suitability of the model for arrayed CRISPR screening.

Contact Us

For more detailed guidance on this funding opportunity, please visit our website.



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