Director of Quantitative Biomarkers

4 weeks ago

Oxford, Oxfordshire, United Kingdom Exscientia Full time
About Exscientia

Exscientia is a pioneering AI-driven precision medicine company dedicated to revolutionizing the discovery, design, and development of innovative drugs. Our cutting-edge platform combines artificial intelligence with human expertise to create personalized treatments for patients. With a strong focus on oncology, we strive to make a meaningful impact on patient outcomes.

The Role

We are seeking a highly skilled Director of Quantitative Biomarkers to lead our preclinical and clinical translational research programs in oncology. As a key member of our team, you will be responsible for designing, implementing, and interpreting biomarker strategies that support early clinical programs. Your expertise will be crucial in defining pharmacodynamic markers to support proof of mechanism determination and informing indication and dosing regimen selection.

As a leader, you will collaborate with multidisciplinary teams, including research biology, drug discovery, in vivo pharmacology, pharmacometrics, genomics, and clinical pharmacology/operations groups. You will also develop external scientific collaborations to gain novel insights from clinical samples into disease biology.

This is a hybrid role, requiring occasional travel to our offices in Oxford, UK (approximately once per quarter), with flexibility to work from home in the UK the remaining time. We offer a flexible working environment, and we're willing to consider other options that provide similar contact time with the team.

Key Responsibilities
  • Develop and deliver clinical biomarker strategies for preclinical and clinical assets, participating in compound development teams and leading pertinent working groups.
  • Analyze, interpret, and present emerging clinical biomarker data, working closely with quantitative clinical pharmacology to support model-informed drug development for clinical programs.
  • Contribute to building scientific rationale to support the clinical strategy, working closely across groups and functions to explore novel indications, targeted patient populations, and new drug combinations for compounds in research, preclinical, and clinical development.
  • Regularly report biomarker data to project teams, line management, and other senior governance groups when necessary.
  • Fulfill regulatory responsibilities, including preparing, updating, and finalizing the biomarker sections in clinical protocols, Investigator Brochures, Clinical Study Reports, and compound development plans.
  • Contribute to the generation of preclinical experimental plans to support the clinical biomarker strategy, supervise the studies, and integrate into clinical development plans.
  • Interact and liaise with internal experts, external experts, academic groups, and CROs to establish collaborations and projects.
Requirements
  • MSc, PhD, or PharmD in immuno-oncology, tumor biology, or a related field.
  • 10+ years of experience conducting quantitative biomarker/translational biology research in a pharmaceutical/biotech setting, including 3+ years of clinical trial experience.
  • Experience in designing and executing pre-clinical research, in-vitro and in-vivo pharmacology, and mechanism of action studies.
  • Leadership experience in drug discovery/development to represent clinical BTB research on project teams and communicate goals and deliverables to senior management and governance committees.
  • Ability to work effectively on multiple oncology programs in a fast-paced environment, with resilience and ability to adapt to changes in priorities.
  • Strong collaboration and teamwork skills, with excellent written and verbal communication.
Benefits
  • Join our inclusive, collaborative, and intellectually stimulating organization with an exciting mission and strong values.
  • As a learning organization, we provide access to learning and development opportunities and will place you at the forefront of your career growth at Exscientia.
  • We employ brilliant people, so we pay highly competitive salaries.
  • Enjoy our generous 28 days holiday allowance plus public holidays, with flexibility to carry over or purchase extra holidays.
  • We also offer flexible working to find a healthy work-life balance that works for you.
  • We're leading the way in progressive leave, offering enhanced policies so you feel supported no matter the life event. This includes generous parental, fertility, menopause, and family emergency leave, and much more.
  • As a healthcare company, we understand the importance of health and wellbeing, so we provide comprehensive private health insurance, dental, and vision benefits for you and your family.
  • We also provide plenty of access to mental health support, including therapy and counseling sessions, plus an employee assistance program for help with lifestyle issues such as bereavement, family problems, or money management.
  • To help safeguard the future for you and your loved ones, we also offer pension and life cover.
  • Have fun with colleagues at our in-person and remote social events. Get competitive at a quiz or bake-off, or relax at a movie night or picnic - there's something for everyone.
  • Collaborate with your team at our uplifting offices and choose a design-led breakout space to inspire creativity. Help yourself to free drinks, snacks, and freshly ground coffee in our fully stocked kitchens. Some of the best ideas start with a coffee break.
  • Learn more about why our team enjoy working at Exscientia here.
DEIB

At Exscientia, we are committed to building a diverse, equitable, and inclusive environment where every employee belongs.

We celebrate and value the diversity of our team, recognizing that our differences drive our creativity and innovation forward. This applies to differences in ethnicity, nationality, cultural heritage, age, religion, mental and physical ability, neurodiversity, gender identity and expression, sexual orientation, marital and civil partnership status, family status, and socioeconomic background.

We are committed to providing fair treatment, opportunity, and advancement for all employees, and we strive to create an inclusive environment where everyone feels valued, respected, and empowered to bring their best selves to work.

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