Structural Biologist with Cryo-EM Expertise

3 weeks ago

Stevenage, Hertfordshire, United Kingdom GSK Full time
Job Description

Structural Biologist with Cryo-EM Experience

GSK's UK Structural & Biophysical Sciences (SBS) group is a global, multi-disciplinary department within R&D that provides molecular insights into drug discovery for small molecule, oligonucleotide, biopharmaceutical, and vaccine programs.

We are seeking a structural biologist with a strong knowledge of electron microscopy, particularly applied to small molecule drug development or vaccine research. The ideal candidate will be motivated to work within a team environment, applying their talents to drive impact on therapeutic projects by collaborating with others.

The successful candidate will have exceptional strengths in one to two specific areas of EM, such as instrument knowledge, challenging sample optimization, software development and processing, or creativity in addressing complex problems. They will be passionate about remaining current in this rapidly evolving field and have a strong track record of success and expertise in one or two specific areas of the cryo-EM process.

The role will involve delivering structural biology results as part of integrated cross-discipline teams to support drug discovery project decisions, designing experiments to ask critical program questions using structural and biophysical approaches, and contributing to the cryo-EM infrastructure of the department.

Key Responsibilities:

  • Deliver structural biology results as part of integrated cross-discipline teams to support drug discovery project decisions.
  • Design experiments to ask critical program questions using structural and biophysical approaches.
  • Contribute to the cryo-EM infrastructure of the department.

Requirements:

  • PhD in a biological, biochemical, or physical sciences discipline.
  • Extensive knowledge of the single-particle cryo-EM process from protein purification to grid optimization, data processing, 3-D reconstruction, and structure interpretation.
  • Demonstrated exceptional track record of success and expertise in one or two specific areas of the cryo-EM process.
  • Success with multiple high-resolution structures, including small proteins and ideally membrane protein complexes.
  • Experience with operation of screening and high-resolution data-collection microscopes.
  • Excellent organization, interpersonal, communication, and team working skills.

Preferred Qualifications:

  • Extensive experience of cryo-EM sample preparation and optimization, including cross-linking and extending to cryo-ET.
  • Expertise in working with challenging systems, including membrane proteins and RNA.
  • Experience in automating single-particle processing or cryo-ET processing.
  • Significant experience in other structural biology or biophysical techniques.
  • Experience of scientific leadership to influence programs of research.
  • Evidence of ability to coordinate projects with interconnecting activities.

Why GSK?

GSK is a global biopharma company with a special purpose – to unite science, technology, and talent to get ahead of disease together. We prevent and treat disease with vaccines, specialty, and general medicines. We focus on the science of the immune system and the use of new platform and data technologies, investing in four core therapeutic areas: infectious diseases, HIV, respiratory/immunology, and oncology.

We want GSK to be a place where people feel inspired, encouraged, and challenged to be the best they can be. A place where they can be themselves – feeling welcome, valued, and included. Where they can keep growing and look after their wellbeing.

As an Equal Opportunity Employer, we are open to all talent. In the US, we also adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to neurodiversity, race/ethnicity, color, national origin, religion, gender, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status, or any other federal, state, or local protected class.*

*US only.

We believe in an agile working culture for all our roles. If flexibility is important to you, we encourage you to explore with our hiring team what the opportunities are.

Should you require any adjustments to our process to assist you in demonstrating your strengths and capabilities, contact us on Ukdiversity.recruitment@gsk.com or 0808 234 4391.

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