Structural Biologist with Cryo-EM Expertise

1 month ago

Stevenage, Hertfordshire, United Kingdom VONQ Full time
Job Description

We are seeking a highly skilled Structural Biologist with cryo-EM experience to join our team at GSK. As a key member of our UK Structural & Biophysical Sciences group, you will play a critical role in providing molecular insights into drug discovery for small molecule, oligonucleotide, biopharmaceutical, and vaccine programs.

Key Responsibilities
  • Deliver structural biology results as part of integrated cross-discipline teams to support drug discovery project decisions.
  • Design experiments to ask critical program questions using structural and biophysical approaches and effectively coordinate this within the department.
  • Contribute to the cryo-EM infrastructure of the department, such as supporting the running of the EM facility or assisting with the computational structural biology infrastructure.
  • Build a collaborative environment, contributing to the innovation and high productivity of the department to advance the application of structure and biophysics in drug discovery.
Requirements
  • A background in a biological, biochemical, or physical sciences discipline, with at least a PhD level or equivalent experience.
  • Extensive knowledge of all stages of the single-particle cryo-EM process from protein purification to grid optimization, data processing, 3-D reconstruction, and structure interpretation.
  • Demonstrated exceptional track record of success and expertise in one or two specific areas of the cryo-EM process.
  • Success with multiple high-resolution structures, including small proteins and ideally membrane protein complexes.
  • Experience with the operation of screening and high-resolution data-collection microscopes.
  • Excellent organization, interpersonal, communication, and team working skills.
Preferred Qualifications
  • Extensive experience of cryo-EM sample preparation and optimization, including cross-linking and extending to cryo-ET, ideally including expertise in protein purification.
  • Expertise in working with challenging systems, including membrane proteins and RNA.
  • Experience in automating single-particle processing or cryo-ET processing.
  • Significant experience in other structural biology or biophysical techniques.
  • Experience of scientific leadership to influence programs of research.
  • Evidence of ability to coordinate projects with interconnecting activities.

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