Senior Scientist

2 weeks ago

York, United Kingdom Labcorp Full time
Job Summary

We are seeking a highly skilled Senior Scientist - Cellular Potency Assay Development to join our team at Labcorp Drug Development Laboratories. As an Assay Development Scientist, you will play a pivotal role in developing and optimizing cell-based potency assays to support projects in all phases of the drug development pipeline.

Main Responsibilities
  • Deliver expertise in cellular potency assay development and optimization for the purpose of implementation in the quality control of drug development projects.
  • Implement new technologies and current scientific thinking in the field of cellular potency assay development while working in partnership with colleagues in the assay development team to ensure that assays are robust and fit for purpose.
  • Implement projects to agreed timelines such that the objectives of the project are met, including delivery of more than one agreed area of work in parallel where appropriate.
  • Contribute novel ideas and use judgment and knowledge where appropriate to influence the work of the project.
  • Maintain an awareness of current developments in the literature, regulations, and scientific community.
  • Train individuals in correct cellular potency assay execution.
  • Act as the subject matter expert during troubleshooting and analytical investigation scenarios both with internal colleagues and external clients.
Requirements
  • A BSc degree in a relevant scientific discipline (e.g. Biochemistry, Biomedical Sciences, Biology) plus relevant postgraduate experience in cellular potency assay design and development, achieved in the pharmaceutical or biotechnology industry or as part of an MSc or PhD program.
  • Extensive experience in the handling and maintenance of mammalian cell cultures.
  • Experience in 96-well plate cell-based bioassays (e.g. cytotoxicity, proliferation, ADCC), ELISA or AlphaLisa.
  • A practical understanding of a wide range of cellular assay methods and technologies (for example fluorescence, luminescence, flow cytometry, TRF) as applied to a range of biological drug targets.
  • Knowledge of GMP regulatory requirements relating to analytical testing and data integrity.
  • Excellent problem-solving skills, strong delivery focus, and communication skills.
Desirable Requirements
  • A PhD in a relevant scientific discipline.
  • Experience in cell bank production.
  • Experience in the automation of plate-based bioassays.
  • Experience in the development of cellular assays for gene and cell therapy products.
  • Knowledge and application of 'design of experiment' in assay design and development.
  • Experience in the use of bioanalytical software (e.g. SoftMax Pro, PLA, QuBAS etc.).

We are an equal opportunities employer and welcome applications from all qualified candidates. If you are an individual with a disability who needs assistance using our online tools to search and apply for jobs, or needs an accommodation, please visit our accessibility site or contact us at Labcorp Accessibility. For more information about how we collect and store your personal data, please see our Privacy Statement.

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