Research Scientist in Cell Biology
2 weeks ago
We are seeking a highly motivated Research Associate to join our team at the Cambridge Institute for Medical Research (CIMR) to work on an MRC research project entitled "Organelle remodelling and function of endolysosomes, lysosomes and secretory lysosomes".
Key Responsibilities:
- Conduct research in cell biology, focusing on the mechanisms regulating lysosomal pH and the assembly of V-ATPase on endolysosomes and disassembly on reforming lysosomes.
- Develop and implement biochemical assays to study protein interactions and subcellular fractionation techniques.
- Collaborate with structural biologists to analyze protein structures using alphafold.
- Design and generate plasmid constructs and stably transfected/transduced mammalian cell lines.
- Perform confocal fluorescence microscopy, electron microscopy, and biochemical assays to study intracellular membrane traffic.
Requirements:
- PhD in cell biology, biochemistry, or a related subject.
- Experience in generating plasmid constructs, stably transfected/transduced mammalian cell lines, confocal fluorescence microscopy, electron microscopy, and biochemical assays.
- Knowledge of intracellular membrane traffic and protein interactions.
- Ability to work independently and collaboratively as part of a team.
About the University:
The University of Cambridge is a world-leading institution with a strong commitment to equality, diversity, and inclusion. We welcome applications from all sections of society and are committed to creating a diverse and inclusive environment.
The Cambridge Institute for Medical Research (CIMR) is a collaborative institute at the interface between fundamental research and the clinic, with a mission to determine the molecular mechanisms of disease to advance human health.
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