Scientist II Role

4 weeks ago

Manchester, United Kingdom Yourgene Health Full time
About the Role:

Yourgene Health is seeking a highly motivated and intellectually engaged Scientist II to join our NGS/Next Generation Sequencing team based at Manchester Science Park. As a key member of our team, you will be responsible for designing, developing, verifying, and validating in vitro diagnostic products and services based on next-generation sequencing platforms. You will also perform general laboratory maintenance activities and contribute to the daily maintenance and running of the laboratory environments.

Key Responsibilities:
  • Design and develop in vitro diagnostic products and services for use in a range of applications.
  • Execute laboratory operations through the day-to-day planning, execution, analysis, and documentation of experiments to the highest standard.
  • Contribute to the daily maintenance and running of the laboratory environments.
  • Work collaboratively within teams to create high-quality products and processes meeting key user needs and to ensure a safe and efficient laboratory environment.
  • Provide scientific expertise and input into experiments through to project work-packages with a focus on developing molecular diagnostic assays on NGS platforms.
  • Lead planning, execution, and reporting of defined project experiments and work-packages.
  • Support cross-functional collaboration, which may also include leading projects.
  • Create, maintain, and improve laboratory SOPs, as well as systems and process SOPs.
  • Lead troubleshooting activities when technical issues arise.
  • Ensure the quality and regulatory requirements of the role, including compliance to SOPs, documentation using electronic lab books, study plans, study reports, and integrity of data are met by themselves and the wider team.

Requirements:
  • Degree or further degree (or equivalent) in a life science such as molecular biology, biochemistry, or genetics.
  • Typically, 3-5+ years of relevant experience.
  • Experience in the development, verification, and validation of molecular diagnostic assays in adherence with CE marking and/or design control regulations.
  • Hands-on experience with at least two molecular biology-based assays and techniques.
  • Capable of independently performing experimental design and execution.
  • Enthusiasm, drive, thoroughness, diligence, and a willingness to take personal responsibility to ensure that projects are successful.
  • Strong data analysis and interpretation skills.
  • Ability to think analytically and troubleshoot.
  • Experience with laboratory processes, including processing biological samples, DNA extraction, Real-Time PCR, and Next Generation Sequencing, preferable.
  • Experience using a variety of NGS platforms, preferably spanning both long read and short read technologies.
  • Meticulous scientific technique and attention to detail.
  • Demonstrate accountability.
  • Able to communicate effectively.
  • Ability to work independently and as part of a team.
  • Good organisational skills and enjoys working to tight timelines.
  • Good written and verbal communication skills and ability to document and present work in a clear, consistent, and concise manner.
  • Flexible attitude to work.
  • Demonstrable planning and problem-solving skills.

About Yourgene Health:

Yourgene Health is a leading integrated technologies and services business, enabling the delivery of genomic medicine. The group works in partnership with global leaders in DNA technology to advance diagnostic science. Yourgene primarily develops, manufactures, and commercialises simple and accurate molecular diagnostic solutions, for reproductive health, precision medicine, and infectious diseases. The Group's flagship in vitro diagnostic products include non-invasive prenatal tests (NIPT) for Down's Syndrome and other genetic disorders, Cystic Fibrosis screening tests, invasive rapid aneuploidy tests, and DPYD genotyping. Yourgene has a range of innovative DNA sample preparation platforms, powered by Ranger Technology, the Yourgene LightBench, and Yourgene QS250, ideal for cell-free DNA applications in NIPT and oncology, including liquid biopsy. Yourgene also has a global laboratory service network equipped to be a full life-cycle partner for clinical, research, and pharmaceutical organisations to support partners at the preclinical, clinical, and post-market stage to develop, manufacture, obtain regulatory approval, and commercialise new products and services. In addition, Yourgene offers an NIPT and high-throughput Covid testing service. Yourgene Health is headquartered in Manchester, UK, with facilities in Taipei, Singapore, the US, and Canada.

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