Senior Pharmacokinetics and Pharmacodynamics Expert

7 days ago

Slough, Slough, United Kingdom Lifelancer Full time

We are seeking a highly skilled and experienced Pharmacokinetics and Pharmacodynamics expert to join our team at Lifelancer. This role will involve driving the nonclinical PKPD strategy for projects, ensuring effective communication and implementation across the organization.

About the Role:

  • Develop and drive the nonclinical PKPD strategy for projects, ensuring translation from in vitro data and in vivo nonclinical studies to prediction of efficacy and safety in patients.
  • Initiate and engage in multifunctional collaborations to facilitate the advancement of drug candidates and build a thorough knowledge of drug pharmacology and PKPD leading to quantitative translation to the clinic.
  • Build PKPD models to allow hypothesis testing and inform decision-making.
  • Provide scientific and technical input, expertise, and leadership to Nonclinical PKPD group project teams and the department.
  • Work in collaborations with external partners, academic institutions, CROs, and consultants as required.
  • Maintain an awareness of new/emerging techniques and tools relevant to the field.
  • Represent the interests of Lifelancer internally and externally in matters relevant to mechanistic PKPD and contribute to enhancing the scientific reputation of NonClinical PKPD.
  • As required, contribute to Due Diligence of external project, product, and technology opportunities.
  • Provide required support and input into regulatory study protocols, reports, and summaries, and regulatory submission documents.

Requirements:

  • PhD in a relevant discipline (pharmacology, bioengineering, pharmacokinetics/pharmacodynamics, etc.).
  • Good understanding of pharmacology and the pharmacology processes related to disease and drug mechanisms.
  • Expertise and proven application of PKPD methods and concepts in support of drug discovery and development. Systems modelling experience would be advantageous.
  • Demonstrated experience in developing and executing effective nonclinical PKPD strategies from early discovery through to clinic.
  • Innovative, self-motivated, team-oriented scientist with good written and verbal communication skills, able to handle several projects at any given time, to work successfully in teams, and to communicate clearly to a variety of audiences.
  • Demonstrated leadership skills in a matrix environment, capable of working effectively in teams and influencing relevant stakeholders.
  • Experience working within a matrix environment with a wide range of internal stakeholders, including NonClinical Safety, Bioanalysis, Clinical Pharmacology, and Translational Medicine.
  • Record of publications and other external scientific contributions relevant to PKPD.
  • Experience in using modelling and simulation packages, such as Phoenix, Berkeley, Madonna, Monolix, and R.

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