In Silico Design Expert

2 weeks ago


Oxford, Oxfordshire, United Kingdom Immunocore Full time

About Us: Immunocore is a pioneering biotechnology company dedicated to developing and commercializing innovative therapies for patients with serious diseases. Our vision is to transform the lives of patients by creating a new generation of precision engineered drugs that harness the immune system to treat a broad spectrum of diseases.

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Job Summary: We are seeking a highly skilled Principal Research Scientist In Silico Biologics Design to join our Protein Engineering team. The successful candidate will be responsible for developing and implementing advanced machine learning models to optimize the design of our T-cell receptor (TCR) drugs.

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Responsibilities:

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  • Develop and assess advanced machine learning models for novel antibody and TCR drug candidate optimization.\
  • Work with colleagues across Research to identify training data from the public domain and help shape the development of our in-house data sets.\
  • Establish virtual screening tools, including protein structure prediction, affinity prediction, peptide human leukocyte antigen (pHLA) specificity prediction, and developability prediction.\
  • Assist with TCR library design for multifactorial lead optimization.\
  • Promote utilization of ML algorithms among colleagues and mentor/train others in their deployment.\
  • Present research outcomes at all levels, including Protein Engineering lab meetings and external conferences.\
  • Contribute to the development of our in-house data sets and ensure their quality and integrity.\
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Requirements:

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  • PhD in Computational Biology, Computational Chemistry, Bioinformatics, or related discipline.\
  • Demonstrated expertise in machine learning, with a strong publication record.\
  • Advanced Python programming skills, focusing on data science and machine learning.\
  • Experience working with large-scale biological datasets and proficiency with data management software.\
  • Excellent communication and collaboration skills, with the ability to work effectively in a fast-paced research environment.\
  • Estimated salary range: £120,000 - £180,000 per annum, depending on experience.\


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