Senior Gene Editing Scientist

2 months ago

North East, United Kingdom ReCode Therapeutics, Inc. Full time
Job Summary

We are seeking a highly skilled and motivated Senior Gene Editing Scientist to join our team at ReCode Therapeutics, Inc. in Durham, NC. As a key member of our gene correction drug development team, you will be responsible for applying advanced gene editing technologies to support our programs and delivery discovery platform function.

Key Responsibilities
  • Lead Gene Editing Research: Design, execute, and optimize experiments using next-generation gene editing and epigenome editing strategies with CRISPR-based tools and beyond.
  • Advance Gene Correction Applications: Develop and implement molecular biology, cell biology, and NGS-based assays to advance gene correction applications for therapeutic and non-viral platform discovery projects.
  • Support Delivery Solution Discovery: Work with primary in vitro cell culture disease models of lung epithelial cells to support the discovery of novel LNP delivery solutions through in vitro and in vivo gene editing screens.
  • Manage and Analyze Data: Generate, manage, evaluate, and maintain critical data in a highly organized manner, providing statistical analysis and troubleshooting where appropriate.
  • Present Experimental Data: Analyze and present experimental data to a wide range of audiences, including senior management and external partners.
  • Troubleshoot and Dissect Published Literature: Troubleshoot and dissect published literature to find novel solutions to resolve technical and/or biological hurdles.
  • Contribute to Cross-Functional Team: Contribute as a key member of a cross-functional drug discovery team that includes gene correction, primary human biology, pharmacology, computational biology, bioanalytical, toxicology, and formulation capabilities.
  • Prepare Reports and Manuscripts: Prepare SOPs, keep an excellent electronic lab notebook and record-keeping entries, and prepare reports and/or manuscripts for publication.
  • Manage Direct Reports: Manage one or more direct reports; mentor additions to the team.
Requirements
  • PhD in Molecular Biology or Related Discipline: PhD in molecular biology, cell biology, biological engineering, or related discipline with 4 years of experience in postdoctoral research and/or industry.
  • Subject Matter Expertise: Subject matter expertise, with a proven track record of publications/patents, in gene editing, with a broad knowledge of gene editing applications.
  • Hands-on Experience with Gene Editing Tools: Hands-on experience using gene editing tools including next-generation CRISPR systems (e.g. Prime or Base editors).
  • Deep Expertise in Analytic RNA or DNA Assays: Deep expertise in analytic RNA or DNA assays to measure and analyze gene editing results.
  • Experience with Bioinformatics Tools: Experience in utilizing bioinformatics tools and software for the analysis of gene editing readouts.
  • Experience with Mammalian Cell and Tissue Culturing: Experience in mammalian cell and tissue culturing is required.
  • Experience with Viral or Non-viral Delivery Platforms: Experience with viral or non-viral delivery platforms, preferably lipid nanoparticles (LNPs) (recommended).
  • Understanding of Lung Biology: Understanding of lung biology and/or rare lung disease (recommended).
  • Excellent Communication Skills: Excellent verbal and written communication skills, with proven ability to write reports and/or articles for publication.
  • Advanced Knowledge of Statistical and Genome Analytical Tools: Advanced knowledge of statistical and genome analytical tools (GraphPad, R, SnapGene).
  • Excellent Project Leadership Skills: Excellent project leadership skills in driving for results and innovation; ability to execute within a matrixed organization.
  • Highly Organized and Collaborative: Extremely organized and able to efficiently manage your time and workflow, including skillfully prioritizing both long-term projects and day-to-day responsibilities. Highly collaborative, team-oriented, and considerate of the needs of others.

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