Postdoctoral Research Scientist

1 month ago

North East, United Kingdom ReCode Therapeutics, Inc. Full time
Senior Scientist - Gene Correction

We are seeking a highly skilled and motivated Senior Scientist to join our team at ReCode Therapeutics, Inc. in Durham, NC. As a key member of our gene correction team, you will be responsible for applying advanced gene editing technologies to support our gene correction programs and delivery discovery platform function.

Responsibilities:

  • Design and execute experiments using next-generation gene editing and epigenome editing strategies with CRISPR-based tools and beyond.
  • Advance gene correction applications for therapeutic and non-viral platform discovery projects through the design, implementation/optimization, and execution of molecular biology, cell biology, and NGS-based assays.
  • Support the discovery of novel LNP delivery solutions through in vitro and in vivo gene editing screens.
  • Work with primary in vitro cell culture disease models of lung epithelial cells.
  • Generate, manage, evaluate, and maintain critical data in a highly organized manner, providing statistical analysis and troubleshooting where appropriate.
  • Analyze and present experimental data to a wide range of audiences.
  • Troubleshoot and dissect published literature to find novel solutions to resolve technical and/or biological hurdles.
  • Contribute as a key member of a cross-functional drug discovery team that includes gene correction, primary human biology, pharmacology, computational biology, bioanalytical, toxicology, and formulation capabilities.
  • Prepare SOPs, keep an excellent electronic lab notebook and record-keeping entries, and prepare reports and/or manuscripts for publication.
  • Manage one or more direct reports; mentor additions to the team.

Qualifications:

  • PhD in molecular biology, cell biology, biological engineering, or related discipline with 4 years of experience in postdoctoral research and/or industry.
  • Subject matter expertise, with a proven track record of publications/patents, in gene editing, with a broad knowledge of gene editing applications.
  • Hands-on experience using gene editing tools including next-generation CRISPR systems (e.g. Prime or Base editors).
  • Deep expertise in analytic RNA or DNA assays to measure and analyze gene editing results.
  • Experience in utilizing bioinformatics tools and software for the analysis of gene editing readouts.
  • Experience in mammalian cell and tissue culturing is required.
  • Experience with viral or non-viral delivery platforms, preferably lipid nanoparticles (LNPs) (recommended).
  • Understanding of lung biology and/or rare lung disease (recommended).
  • Excellent verbal and written communication skills, with proven ability to write reports and/or articles for publication.
  • Advanced knowledge of statistical and genome analytical tools (GraphPad, R, SnapGene).
  • Excellent project leadership skills in driving for results and innovation; ability to execute within a matrixed organization.
  • Extremely organized and able to efficiently manage your time and workflow, including skillfully prioritizing both long-term projects and day-to-day responsibilities.
  • Highly collaborative, team-oriented, and considerate of the needs of others.
  • Desire to work in a fast-paced environment and contribute to developing the next generation of gene editing.

Position is based in Durham; role provides relocation for candidates not living in Durham.

Salary Range: $120-130k - Please note that for remote positions, salary may be adjusted for cost of living.

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