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Senior Medicinal Chemist
2 months ago
We are seeking a highly skilled and experienced Principal Scientist, Medicinal Chemistry to join our team at Flagship Pioneering. As a key member of our organization, you will play a critical role in designing and executing medicinal chemistry strategies that support biology validation and drug discovery from hit finding to lead generation, lead optimization, and candidate selection.
Key Responsibilities- Medicinal Chemistry Leadership: Discover and advance novel chemical entities (small molecules, protacs, molecular glues) into clinical development.
- Strategy Development: Define, implement, and execute on medicinal chemistry strategies from hit ID to lead generation, lead optimization, and candidate selection.
- Team Management: Provide strategic, scientific, and managerial leadership to external CRO med chem teams.
- Project Leadership: Serve as project and chemistry lead for drug discovery programs.
- Intellectual Property: Collaborate with the IP team to create and execute strategy to establish, protect, and expand intellectual property.
- Communication: Communicate, collaborate, and coordinate effectively within cross-functional teams.
- Research Presentation: Effectively present and communicate research findings at internal meetings and external scientific conferences.
- Education: Ph.D. in Organic Chemistry or Medicinal Chemistry with a minimum of 10+ years of relevant drug discovery experience in the biotech/pharmaceutical industry.
- Experience: Experienced in all aspects of medicinal chemistry, including use of tool/probe compounds, hit ID and follow-up, hit-to-lead chemistry, and lead optimization to candidate selection.
- Background: Broad background in all aspects of drug discovery, including SBDD, physicochemical property-driven optimization (MPO), and computational chemistry.
- Knowledge: Working knowledge of structural biology, ADME/PK, in vitro assays, and in vivo pharmacology.
- Relationship Building: Experience in managing and building strong relationships with chemistry CROs.
- Leadership: Demonstrated success in leading medicinal chemistry and projects teams to deliver high-quality compounds into development.
- Additional Skills: Experience in oligonucleotide drug discovery is a plus. Ability to accommodate rapidly changing priorities and deadlines. Excellent communication and project leadership skills and ability to work effectively in a cross-functional team setting. Proven track record for striving for a high level of innovation and scientific excellence.
