Postdoctoral Researcher in De Novo Metalloenzyme Design

2 weeks ago


London, Greater London, United Kingdom University of Bristol Full time

A postdoctoral research position is available in the Protein Design Laboratory of Prof Dek Woolfson at the University of Bristol to develop new metalloprotein scaffolds and elaborate these into de novo enzymes.

The appointed post-doc would design de novo metalloenzymes based on new alpha-helical barrel proteins using computational design, and protein biochemistry.

Specifically, the work will develop de novo alpha-helical barrel proteins recently designed by the Woolfson group, based on its foregoing peptide assemblies. These alpha-helical barrel peptides and proteins have solvent-accessible channels running completely through them, which can be modified through rational or computational design to incorporate new functions.

The aim of this project is to design alpha-helical barrel proteins that bind metal and metal clusters capable of facilitating catalytic reactions.

Essential skills for the role include experience with the design or engineering and production of natural or de novo proteins, and the biophysical and structural characterisation of proteins, including crystallography. Experience in enzymology would be an advantage.



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