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DMPK Project Lead

2 months ago

Slough, Slough, United Kingdom Lifelancer Full time
Job Title: DMPK Project Lead

We are seeking a highly skilled DMPK Project Lead to join our team at Lifelancer. As a key member of our research and development organization, you will be responsible for leading projects from early discovery to clinical phases, ensuring the successful development of new compounds.

Key Responsibilities:
  • Design and execute experimental studies to support project goals and deliver data to inform decision-making.
  • Collaborate with cross-functional teams to integrate DMPK expertise into project planning and execution.
  • Develop and maintain a deep understanding of preclinical pharmacokinetics, toxicokinetics, and related disciplines.
  • Apply expertise in physical properties, DMPK, and enzymology to inform compound design and optimization.
  • Work with project teams to resolve ADME challenges and mitigate risks.
  • Contribute to the development of new approaches and technologies to support DMPK science.
  • Prepare and review DMPK sections of regulatory documents, including IND, IMPD, and NDA submissions.
  • Participate in research aligned to DMPK and UCB's portfolio to publish research papers in internationally recognized journals.
Requirements:
  • PhD (or equivalent) in Pharmaceutics, Pharmacology, Drug Metabolism, or Pharmacokinetics, with 7 years of postdoctoral industrial experience, or a related degree with 10 years of industrial experience in DMPK science.
  • Comprehensive understanding of discovery and development DMPK, including modeling and simulation, and a proven ability to delineate the impact of chemical structure on measured properties.
  • Wide experience in pharmaceutical R&D, including knowledge of regulatory requirements and experience working with regulatory agencies.
  • Recognized track record of experience in DMPK/ADME and excellent knowledge in ADME/Enzymology/Drug Transporters.
  • Proven skills for in-depth mechanistic understanding of DMPK-related issues and the impact and value of translation to humans.
  • Knowledge of the drug development processes in the Pharma Industry environment.