DMPK Project Lead

4 weeks ago

Slough, Slough, United Kingdom Lifelancer Full time
Job Title: DMPK Project Lead

We are seeking a highly skilled DMPK Project Lead to join our team at Lifelancer. As a key member of our research and development team, you will be responsible for leading projects from early discovery to clinical phases, ensuring the successful development of new compounds.

Key Responsibilities:
  • Design and execute experimental studies to support project goals and deliver data to internal and regulatory stakeholders.
  • Develop and maintain a deep understanding of preclinical pharmacokinetics, toxicokinetics, and related disciplines to inform project decisions.
  • Collaborate with cross-functional teams to resolve ADME challenges and ensure project success.
  • Stay up-to-date with the latest DMPK science and technologies to champion innovative approaches and ensure UCB stays at the forefront of DMPK science.
  • Prepare and submit high-quality DMPK sections for internal and regulatory documents.
  • Contribute to research aligned with UCB's portfolio and publish research papers in internationally recognized journals.
  • Provide scientific mentorship to support junior staff in their personal and professional development.
Requirements:
  • PhD or equivalent in Pharmaceutics, Pharmacology, Drug Metabolism, or Pharmacokinetics with 7 years of postdoctoral industrial experience, or a related degree with 10 years of industrial experience in DMPK science.
  • Comprehensive understanding of discovery and development DMPK, including modeling and simulation, and a proven ability to delineate the impact of chemical structure on measured properties.
  • Wide experience in pharmaceutical R&D, including knowledge of regulatory requirements and experience working with regulatory agencies to fulfill DMPK contributions to new drug submissions.
  • Recognized track record of experience in DMPK/ADME and excellent knowledge in ADME/Enzymology/Drug Transporters and knowledge of how to couple data to optimization/selection of NCE both in discovery and development.
  • Proven track record of leading, understanding, and hands-on experience of drug metabolism and pharmacokinetics, both in vitro and in vivo studies, human PK prediction, DDI prediction, and mechanistic understanding to support late-stage programs.
  • Understanding of PKPD and preferably an understanding of PBPK modeling.
  • Proven skills for in-depth mechanistic understanding of DMPK-related issues and of the impact and value of translation to humans.
  • Knowledge of the drug development processes in the Pharma Industry environment.

Lifelancer is a talent hiring platform in Life Sciences, Pharma, and IT. We connect talent with opportunities in biotech, health sciences, healthtech, data science, and IT domains. Please use the below Lifelancer link for job application and quicker response.

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Remote Work: No

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