DMPK Project Lead

1 day ago

Slough, Slough, United Kingdom Lifelancer Full time

About the Role

We are seeking a highly skilled DMPK Project Lead to join our Pharmaceutical Research team. In this role, you will be responsible for leading projects from early discovery to candidate selection and into clinical phases of development.

  • Design and execute experimental studies to deliver data and interpretations to support project goals.
  • Develop and maintain expert understanding of preclinical pharmacokinetics and related disciplines.
  • Apply understanding of physical properties, DMPK, and enzymology to input into the design of new compounds.
  • Work with project colleagues to resolve or mitigate project-related ADME challenges.
  • Champion new innovative approaches to project support and ensure our organization stays at the forefront of DMPK science.
  • Prepare DMPK sections of internal and regulatory documents.
  • Participate in research aligned to our portfolio to publish research papers in internationally recognized journals.
  • Provide scientific mentorship to support junior staff in their personal development.

Requirements

  • PhD (or equivalent) in Pharmaceutics, Pharmacology, Drug Metabolism, or Pharmacokinetics with 7 years of Post-Doctoral Industrial experience; or a related degree with 10 years industrial experience in DMPK science.
  • Comprehensive understanding of discovery and development DMPK, including modeling and simulation.
  • Wide experience in pharmaceutical R&D, including knowledge of regulatory requirements and experience working with regulatory agencies.
  • Recognized track record of experience in DMPK/ADME, excellent knowledge in ADME/Enzymology/Drug Transporters, and knowledge of how to couple data to optimization/selection of NCE.
  • Proven track record of leading, understanding, and hands-on experience of drug metabolism and pharmacokinetics studies.
  • Understanding of PKPD and preferably an understanding of PBPK modeling.
  • Proven skills for in-depth mechanistic understanding of DMPK-related issues and of the impact and value of translation to humans.
  • Knowledge of the drug development processes in the Pharma Industry environment.

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