Senior Research Scientist

4 weeks ago


London, Greater London, United Kingdom The Francis Crick Institute Full time

Job Title: Senior Laboratory Research Scientist

Senior Laboratory Research Scientist – Screening Scientist

We are seeking a highly skilled Senior Laboratory Research Scientist to join our team at the Francis Crick Institute. As a key member of our Molecular Glue Discovery Partnership, you will play a crucial role in developing systematic approaches to exploit endogenous protein degradation pathways.

Working closely with researchers from Imperial College and AstraZeneca, you will combine fundamental biology with proteomics, high throughput screening, protein engineering, and chemical biology approaches to discover and develop new molecular glues.

The successful candidate will have a strong background in biochemistry, cell biology, or a related field, with experience in high throughput screening and assay development. You will be able to maintain a productive dialogue with facility users, educate users in techniques and use of specific machines, and quickly understand and appreciate unfamiliar areas of biology.

Key Responsibilities:

  • Develop and execute proximity-based cell screens and cell-free assays for the identification and validation of molecular glue degraders
  • Collaborate with researchers to co-develop assays, plan and conduct large-scale screens balancing multiple projects simultaneously
  • Maintain a high level of technical expertise and stay up-to-date with the latest developments in the field

Requirements:

  • PhD in biochemistry, cell biology, or a related field
  • Previous direct experience of HTS campaigns in either Pharma or academia
  • Ability to work independently and as part of a team
  • Excellent communication and interpersonal skills

Equality, Diversity & Inclusion:

Diversity is essential to excellence in scientific endeavour. We particularly welcome applications from individuals who are underrepresented in the field. All appointments will be made on merit, and we particularly welcome applications from individuals who are underrepresented in the field.


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