PhD Researcher in Multi-modal Spatial Data Integration for Breast Cancer Treatment Response

3 weeks ago


Cambridge, Cambridgeshire, United Kingdom Cancer Research UK Cambridge Institute Full time

Project Overview

Cancer Research UK Cambridge Institute is seeking a highly motivated PhD researcher to join our team and contribute to a groundbreaking project focused on multi-modal spatial data integration for breast cancer treatment response.

Research Context

Breast cancer patients exhibit highly variable responses to different treatments, and the biological basis of these differences remains obscure. The spatial architecture of tumours is likely a major contributor, and novel technologies for multiplexed molecular measurements of tumour tissues that preserve spatial relationships offer the opportunity to precisely dissect the contribution of the spatially resolved multicellular tumour ecosystem as a response driver.

Project Objectives

The successful candidate will be responsible for collating diverse data, placing them in a shared coordinate space, and unpicking the critical correlations that underpin treatment effect. This project offers the opportunity to build multi-modal predictive models that will be tested in independent datasets with the real potential to surpass the current state-of-the-art.

Methodology

The researcher will work on a large and unique collection of multi-modal spatial data from hundreds of breast cancer patients enrolled in neoadjuvant immunotherapy trials. They will receive extensive training in cancer pathology, highly multiplexed imaging, and predictive modelling.

Requirements

We welcome applications from graduates from quantitative disciplines such as computer science and mathematics, but we also encourage applications from biologists already experienced in computational methods. The ideal candidate will have a strong background in data analysis and machine learning, as well as excellent communication and teamwork skills.

Funding and Duration

This four-year studentship is funded by Cancer Research UK Cambridge Institute and includes full funding for University fees and a stipend of £21,000 per annum for four years.

How to Apply

Please apply via the University Applicant Portal. For further information about the course and to access the Applicant Portal, visit: https://www.postgraduate.study.cam.ac.uk/courses/directory/cvcrpdmsc



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