Senior Cellular Pharmacologist

1 month ago


Oxford, Oxfordshire, United Kingdom Nucleome Full time
Job Description

We are seeking a highly skilled Senior Cellular Pharmacologist to join our team at Nucleome Therapeutics. As a key member of our drug discovery team, you will be responsible for developing primary and secondary assays for evaluation of early biologics drug molecules, engaging in mechanism of action studies, and supporting the progression of multiple asset programmes in early drug discovery.

Key Responsibilities
  • Design, execute, and analyse cellular pharmacology experiments in primary immune cells independently.
  • Develop assays to test therapeutic hypotheses, investigate the pharmacology of tool and candidate molecules, and characterise the biological impact of drug molecules in 'on target' and 'off target' cell types.
  • Collaborate with cross-functional teams to advance drug discovery programmes.
  • Stay up-to-date with the latest developments in cellular immunology and pharmacology.
Requirements
  • PhD qualification in a relevant field (e.g., immunology, autoimmunity, or immuno-oncology) together with experience within a biopharma or academic setting or equivalent work experience within biopharma.
  • Direct practical experience in conceiving, developing, and performing multi-parameter flow cytometry, ELISA (ideally a multiplex system).
  • Experience of analysing and presenting data using FlowJo and GraphPad Prism software.
  • Strong communication skills and ability to communicate complex ideas to specialists and non-specialists at project and functional team meetings.
About Nucleome Therapeutics

Nucleome Therapeutics is a fast-growing biopharma company dedicated to decoding and mining the regulatory 'dark matter' of the human genome to transform drug target discovery and deliver first-in-class precision medicine for autoimmune diseases. We are building a rewarding and fun environment where people embrace creative ways of thinking, take smart risks, and feel empowered to make a difference.



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