Senior Scientist

4 weeks ago

Oxford, United Kingdom Northreach Full time
Job Description

Northreach is a dynamic recruitment agency that connects businesses with top talent in the Advanced Therapies sector. Our mission is to provide a seamless and personalised recruitment experience for clients and candidates, and to create a positive work environment that encourages equality, innovation, and professional growth.


We are exclusively partnered with an innovative biotech start-up, recently spun out of the University of Oxford, on a mission to redefine the sensitivity of Chimeric Antigen Receptors (CARs) and T-Cell Receptors (TCRs) to better target high-value antigens. Our goal is to push the boundaries of TCR and CAR engineering, creating next-generation immunotherapies with unmatched specificity and efficacy in solid tumors and other high-value indications.


Responsibilities


  • Lead and execute in vitro potency assays and functional assays to evaluate and enhance the sensitivity of engineered CARs and TCRs against specific targets.
  • Design and conduct complex preclinical studies, optimizing protocols for TCR-T and CAR-T cell development.
  • Perform high-throughput screening, cellular proliferation, and cytotoxicity assays to validate efficacy and specificity of TCR-T/CAR-T candidates.
  • Develop and refine methodologies for immunophenotyping, flow cytometry, and cytokine release assays, evaluating cell therapy constructs under diverse conditions.
  • Analyze and interpret complex data, generating insights to guide further engineering efforts and ensure product quality.
  • Collaborate closely with cross-functional teams in cell engineering, bioinformatics, and translational research.
  • Stay abreast of recent advances in T-cell engineering and immuno-oncology, contributing innovative ideas to the strategic R&D roadmap.


Requirements

  • Ph.D. in Immunology, Cell Biology, Molecular Biology, or a related field, with 3+ years of relevant biotech or pharma experience; MSc with significant biotech experience may also be considered.
  • Hands-on experience with CAR-T or TCR-T cell development, ideally in preclinical settings within biotech or start-up environments.
  • Expertise in in vitro potency assays, functional assays, cytotoxicity, and cytokine release assays.
  • Proficiency in flow cytometry, immunophenotyping, and other cell-based assays to characterize engineered T cells.
  • Demonstrated ability to work independently, interpret complex data, and generate actionable insights.
  • Collaborative mindset, excellent communication skills, and ability to thrive in a dynamic start-up environment.



Northreach is an equal opportunity employer and we do not discriminate against any employee or applicant for employment based on race, colour, religion, sex, national origin, disability, or age. We are committed to promoting diversity, equity, and inclusion in the workplace and hiring practices, therefore only partner with business that promote DEI. We strive to create a welcoming and inclusive environment for all employees.

  • Senior Scientist

    4 weeks ago

    Oxford, Oxfordshire, United Kingdom Chadwick Nott Full time

    Life Sciences Senior AssociateAt Chadwick Nott, we are seeking a highly skilled Senior Scientist to join our team in the life sciences sector. Our client is a market leader in this area, providing comprehensive advice and legal support to pharmaceutical and biotechnology clients.Key Responsibilities:Provide comprehensive advice to clients on regulatory...

  • Senior Scientist

    4 weeks ago

    Oxford, Oxfordshire, United Kingdom Corriculo Ltd Full time

    Senior Imaging Scientist, MR Physics, Neuroimaging, diffusion MRI, Sponsorship available, COR7006 The Role This is an excellent Senior Imaging Scientist role, working for a company with a growing reputation in their field. The Senior Imaging Scientist will use knowledge gained from a PhD in a relevant field such as MR Physics, Neuroimaging or similar, as...

  • Senior Scientist

    1 month ago

    Oxford, United Kingdom Hyper Recruitment Solutions Full time

    We are currently looking for a Senior Scientist Analytical Development to join a leading biopharmaceutical company based in Oxfordshire. As the Senior Scientist - Analytical Development, you will be responsible for developing, optimizing, qualifying, and validating analytical methods to evaluate both drug substances and drug products from preclinical through...

  • Senior Innovation Scientist

    1 week ago

    Oxford, Oxfordshire, United Kingdom Oxford Biomedica Full time

    Unlock Your Potential as a Senior Innovation ScientistOxford Biomedica, a leading viral vector CDMO, is seeking an experienced Senior Innovation Scientist to join our team. This role offers a highly competitive salary of £80,000 - £110,000 per annum.We are at the forefront of cell and gene therapy, delivering life-changing therapies to patients worldwide....

  • Senior Scientist

    3 weeks ago

    Oxford, United Kingdom CV-Library Full time

    CK Group are recruiting for an experienced Senior Scientist with a strong background in cancer biology (including in vivo experiments), to join a growing biotechnology company, on a permanent basis to be based in Oxford. This is a great opportunity for a highly motivated scientist with a commitment to research on anti-cancer therapies to take responsibility...

  • Senior Scientist

    1 day ago

    Oxford, United Kingdom CK Group- Science, Clinical and Technical Full time

    CK Group are recruiting for an experienced Senior Scientist with a strong background in cancer biology (including in vivo experiments), to join a growing biotechnology company, on a permanent basis to be based in Oxford. This is a great opportunity for a highly motivated scientist with a commitment to research on anti-cancer therapies to take responsibility...

  • Senior Data Scientist

    3 weeks ago

    Oxford, Oxfordshire, United Kingdom Austin Fraser Full time

    Austin Fraser is proud to support a pioneering international software company in London seeking an experienced Senior Data Scientist to join their team on a permanent basis.You will be part of a small group of 3-4 professionals, focusing on delivering end-to-end solutions as well as contributing to their flagship product, a data platform utilizing advanced...

  • Senior Quantitative Scientist

    1 week ago

    Oxford, Oxfordshire, United Kingdom Nightingale Health Full time

    About the Role:We are seeking an experienced Senior Quantitative Scientist to join our team at Nightingale Health in Oxford/London, UK. As a member of our data science team, you will play a key role in developing and implementing predictive models for chronic diseases.In this role, you will work with large datasets of molecular and clinical measurements to...

  • Senior Scientist

    1 week ago

    Oxford, Oxfordshire, United Kingdom Hyper Recruitment Solutions Full time

    About the RoleWe are seeking an experienced Senior Scientist to join our team in Oxfordshire, where you will play a crucial role in developing, optimizing, and validating analytical methods for drug substances and products.Key Responsibilities:Manage the development, qualification, and validation of analytical test methods and technology transfer.Support...

  • Senior Scientist

    3 weeks ago

    Oxford, United Kingdom CK Group Full time

    CK Group are recruiting for an experienced Senior Scientist with a strong background in cancer biology (including in vivo experiments), to join a growing biotechnology company, on a permanent basis to be based in Oxford. This is a great opportunity for a highly motivated scientist with a commitment to research on anti-cancer therapies to take responsibility...

  • Senior Scientist

    3 weeks ago

    Oxford, United Kingdom CK Group Full time

    CK Group are recruiting for an experienced Senior Scientist with a strong background in cancer biology (including in vivo experiments), to join a growing biotechnology company, on a permanent basis to be based in Oxford. This is a great opportunity for a highly motivated scientist with a commitment to research on anti-cancer therapies to take responsibility...

  • Senior NGS Research Scientist

    2 months ago

    Oxford, United Kingdom CV-Library Full time

    Senior NGS Research Scientist Location – Oxfordshire Our client is a leading provider of Next Generation Sequencing (NGS) solutions to support the ongoing development of genetic-based medicine. An opportunity has now become available for an experienced NGS scientist to join the company and support with the product development projects within their...

  • Senior Research Scientist

    4 weeks ago

    Oxford, Oxfordshire, United Kingdom Immunocore Full time

    Immunocore's Senior Research Scientist RoleWe are seeking a highly skilled Senior Research Scientist to join our team at Immunocore. As a talented molecular biologist and innovator, you will be responsible for providing deep scientific and technical expertise in antibody research, including antibody fragments such as scFv and VHH, bispecifics, and...

  • Senior Scientist

    3 weeks ago

    Oxford, United Kingdom CK Group- Science, Clinical and Technical Full time

    CK Group are recruiting for an experienced Senior Scientist with a strong background in cancer biology (including in vivo experiments), to join a growing biotechnology company, on a permanent basis to be based in Oxford. This is a great opportunity for a highly motivated scientist with a commitment to research on anti-cancer therapies to take responsibility...

  • Wet Lab Scientist

    1 week ago

    Oxford, Oxfordshire, United Kingdom Immunocore Full time

    Senior Wet Lab Scientist Wanted!We are seeking a highly skilled Senior Wet Lab Scientist to join our team at Immunocore. As a Senior Asset Scientist, you will be responsible for validating AML targets and contributing to the development of innovative precision engineered drugs.About the OpportunityYou will have the opportunity to work independently as a...

  • Senior NGS Research Scientist

    1 month ago

    Oxford, Oxfordshire, United Kingdom Taylorollinson Full time

    Job Title: Senior NGS Research ScientistJob Summary:We are seeking an experienced NGS Research Scientist to join our team at Taylorollinson. As a key member of our R&D team, you will be responsible for leading technical projects and overseeing the development of NGS assays.Key Responsibilities:Act as technical lead on R&D projects for the improvement and...

  • Senior Research Scientist in Tumor Immunotherapy

    2 days ago

    Oxford, Oxfordshire, United Kingdom University of Oxford, Department of Engineering Science Full time

    Job Title: Senior Research Scientist in Tumor ImmunotherapyLocation: University of Oxford, Department of Engineering ScienceThe University of Oxford, Department of Engineering Science is seeking a full-time Senior Research Scientist to join an interdisciplinary research team developing new techniques for ultrasound-mediated immune-modulation at the Institute...

  • Senior Research Scientist

    2 weeks ago

    Oxford, Oxfordshire, United Kingdom CK Group Full time

    Job OverviewCK Group is a leading biotechnology company based in Oxford, seeking an experienced Senior Scientist with a strong background in cancer biology to join their research team on a permanent basis.The Role:This position involves contributing to strategic R&D goals by designing, managing, and performing studies to support candidate development and...

  • Senior Artificial Intelligence Research Scientist

    2 weeks ago

    Oxford, Oxfordshire, United Kingdom IC Resources Full time

    IC Resources seeks a highly skilled Senior AI Research Scientist in Oxford, UK to accelerate scientific simulations using minimal data and high accuracy.Company OverviewWe are a leading provider of innovative solutions for industrial products. Our mission is to push the boundaries of technology and make a real impact.Job SummaryThis is an exciting...

  • Senior Clinical Scientist Expert

    3 weeks ago

    Oxford, Oxfordshire, United Kingdom Oxford University Hospitals NHS Foundation Trust Full time

    About the RoleWe are seeking a highly skilled Senior Clinical Scientist to join our Imaging Physics and Radiation Protection team at Oxford University Hospitals NHS Foundation Trust.The successful candidate will work alongside a team of Scientists and Technologists to provide comprehensive scientific support in the fields of radiological imaging, supporting...