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Cambridge, Cambridgeshire, United Kingdom Bicycle Therapeutics Full timeJob SummaryWe are seeking a highly motivated Research Scientist to join our Protein & Cellular Sciences Team at Bicycle Therapeutics. As a key member of our team, you will be responsible for acquiring and producing high-quality cellular and recombinant protein material to support our Bicycle discovery platform.Key ResponsibilitiesSupply high-quality protein...
Protein Research Scientist
4 weeks ago
We are seeking a highly skilled Research Scientist to join our Protein & Cellular Sciences Team at Bicycle Therapeutics. As a key member of our team, you will be responsible for designing and producing high-quality cellular and recombinant protein material to support our Bicycle Discovery platform.
Your primary focus will be on working with our team to deliver protein & cellular reagents, which will involve designing and producing cell pools or cell lines to enable the selection and characterization of novel peptides identified by our Bicycle Screening platform. You will also be responsible for providing protein scientists with samples suitable for protein purification.
This role will involve a mix of routine and non-standard work, with an initial split of 3:2. You will be working in a fast-paced, dynamic environment and will need to be comfortable with close interactions within our Protein & Cellular Sciences and wider Platform Technology & Science teams.
Key Responsibilities:- Supply High-Quality Protein & Cellular Material: Support research into target biology and sourcing of necessary reagents to evaluate new targets, generate stable cell pools or cell lines, and quantify protein expression by flow cytometry and Western Blot.
- Contribute to Tissue Culture Facility Maintenance: Act as point contact for DNA & cell bank ordering and inventory management, maintain adherent and suspension cells to supply the wider team, and maintain laboratories, equipment, and reagents stocks.
- Present Data and Conclusions: Help present data and conclusions to project teams in oral or written form, including possible next steps to drive projects forward, and interact and communicate efficiently in a collaborative environment involving cross-functional teams.
- Work to Existing SOPs and Risk Assessments: Contribute to generating new protocols as appropriate and work to existing SOPs and risk assessments.
- Educated in life sciences relevant to the above or equivalent qualification.
- Experience of working in a biotech or industrial environment or equivalent.
- Molecular Biology: Experience in design & propagation of DNA expression plasmids (restriction enzymes).
- Mammalian cell culture experience (aseptic technique, subculture of suspension and/or adherent cell lines, transfection, cryopreservation, etc.).
- Theoretical knowledge of flow cytometry.
- Strong interpersonal skills, confident and experienced in presenting data.
- Diligent in documenting work and adherent to data integrity requirements.
- Practical experience of flow cytometry & cell sorting.
- Molecular biology experience in DNA assembly and cloning (Gibson, HiFi, Golden Gate).
- Experience in protein expression analysis (qPCR, SDS-PAGE & Western Blotting) and subsequent purification (AKTA).
- Experience in using data analysis software packages and ELNs e.g. Dotmatics and GraphPad Prism.
- State-of-the-art campus environment with on-campus restaurant and Montessori nursery.
- Flexible working environment.
- Competitive reward including annual company bonus.
- Employee recognition schemes.
- 28 days annual leave in addition to bank holidays + option to buy up to 5 additional days annually.
- Employer contribution to pension (employee does not have to contribute).
- Life assurance cover 4x basic salary.
- Private Medical Insurance, including optical and dental cover.
- Group income protection.
- Employee assistance program.
- Health Cash Plan.
- Access to company subsidized gym membership.
- Eligibility for an option grant to subscribe to shares in Bicycle Therapeutics plc.
- Cycle to work scheme.
Bicycle Therapeutics is committed to building a diverse workforce that is representative of the communities we serve. We recognize that diverse and inclusive teams build a stronger and more innovative company. Therefore, all qualified applicants will be considered for employment, and we do not discriminate on the basis of race, religion, colour, gender, sexual orientation, age, disability status, marital status, or veteran status.
