Medicinal Chemist for Protein Degradation Therapies

3 days ago


London, Greater London, United Kingdom The Francis Crick Institute Full time

Protein Degradation Therapies Job Description

We are seeking a highly skilled and ambitious Medicinal Chemist to join our team at the Francis Crick Institute. As part of our Molecular Glue (MG) Discovery Partnership with AstraZeneca and Imperial College London, you will contribute to the discovery and development of novel molecular glues for therapeutic applications.

About the Role

  • Design and synthesise small molecule probes for molecular glue discovery and validation.
  • Characterise the molecular mechanism of action of small molecule glues using biophysical assays and crystallography.
  • Contribute to the development of high-throughput screening assays for molecular glue validation.

Requirements

  • PhD (or equivalent experience level) in a relevant discipline such as chemical biology, medicinal chemistry or synthetic organic chemistry.
  • A strong track record of developing innovative solutions to chemical biology or medicinal chemistry questions in academic or industrial research.
  • Deep knowledge of Medicinal Chemistry principles for the design and optimisation of small molecule ligands.

About Us

The Francis Crick Institute is a world-leading research institute focused on biomedical science. We combine rigour with an open and collaborative culture, reflecting our status as a partnership of six organisations aiming to pool knowledge, ideas and resources.

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