Senior Medicinal Chemist

4 weeks ago

Cambridge, Cambridgeshire, United Kingdom Flagship Pioneering Full time
Principal Scientist, Medicinal Chemistry

Flagship Pioneering is seeking a highly motivated and experienced Principal Scientist, Medicinal Chemistry to join our team. This is an exciting opportunity to design and execute medicinal chemistry strategies that will support biology validation and drug discovery from hit finding to lead generation, lead optimization, and candidate selection.

Key Responsibilities:

  • Discover and advance novel chemical entities (small molecules, protacs, molecular glues) into clinical development
  • Define, implement, and execute on medicinal chemistry strategies from hit ID to lead generation, lead optimization, and candidate selection
  • Provide strategic, scientific, and managerial leadership to external CRO med chem teams
  • Serve as project and chemistry lead for drug discovery programs
  • Collaborate with the IP team to create and execute strategy to establish, protect, and expand intellectual property
  • Communicate, collaborate, and coordinate effectively within cross-functional teams
  • Effectively present and communicate research findings at internal meetings and external scientific conferences

Job Qualifications:

  • Ph.D. in Organic Chemistry or Medicinal Chemistry with a minimum of 10+ years of relevant drug discovery experience in the biotech/pharmaceutical industry
  • Experienced in all aspects of medicinal chemistry, including use of tool/probe compounds, hit ID and follow-up, hit-to-lead chemistry, and lead optimization to candidate selection
  • Broad background in all aspects of drug discovery, including SBDD, physicochemical property-driven optimization (MPO), and computational chemistry
  • Working knowledge of structural biology, ADME/PK, in vitro assays, and in vivo pharmacology
  • Experience in managing and building strong relationships with chemistry CROs
  • Demonstrated success in leading medicinal chemistry and projects teams to deliver high-quality compounds into development
  • Experience in oligonucleotide drug discovery is a plus
  • Track record of delivering on project and company goals
  • Ability to accommodate to rapidly changing priorities and deadlines
  • Excellent communication and project leadership skills and ability to work effectively in a cross-functional team setting
  • Proven track record for striving for a high level of innovation and scientific excellence

Location: Cambridge, MA

About Flagship Pioneering

Flagship Pioneering is a biotechnology company that invents and builds platform companies, each with the potential for multiple products that transform human health or sustainability.

Flagship Pioneering and our ecosystem companies are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity, or Veteran status.

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