Senior Laboratory Research Specialist

2 days ago


London, Greater London, United Kingdom The Francis Crick Institute Full time
Job Title:

Senior Laboratory Research Specialist

About the Role:

We are seeking a highly skilled and experienced Senior Laboratory Research Specialist to join our team at The Francis Crick Institute. As a key member of our Proteomics Scientific Technology Platform (STP), you will drive forward qualitative and quantitative proteomic and clinical proteomic projects, from experimental design through sample preparation to data analysis.

This is an excellent opportunity for a talented and motivated individual to contribute to our mission of discovery without boundaries. You will be part of a dynamic and collaborative environment, working closely with researchers, clinicians, and scientists from various disciplines to advance our understanding of human disease and develop innovative treatments.

About the Team:

The Francis Crick Institute is a world-leading research organisation that brings together expertise in biology, physics, chemistry, medicine, engineering, and computer science to understand human health and disease. Our STP provides access to cutting-edge instrumentation and expertise across the range of applications necessary for modern biomedical research, including proteomics.

Key Responsibilities:
  • Driving forward qualitative and quantitative proteomic and clinical proteomic projects, from experimental design through sample preparation to data analysis.
  • Performing both standard and bespoke proteomics experiments starting with sample preparation from a variety of biological sources using common biochemical methodologies for cell lysis, SDS-PAGE, in-gel, in-solution, TCA and acetone precipitation digest protocols, TMT labelling, high pH chromatographic fractionation and label free quantification.
  • LC-MS/MS nanoUHPLC data acquisition, evaluation, and processing of raw data.
Requirements:
  • A PhD or equivalent experience gained through working in a mass spectrometry laboratory, including basic and advanced proteomic sample handling and processing protocols, and familiarity with instrument maintenance requirements.
  • Direct experience with either the Thermo Scientific Orbitrap Tribrid platform or the Bruker timsTOF Ultra/Pro2.
  • Detailed understanding of proteomics related bioinformatics and associated software packages such as PEAKS, Mascot, Scaffold, MaxQuant, Spectronaut, DIA-NN and Skyline.
Benefits:

We offer a competitive salary of £62,000 - £72,000 per annum, depending on experience, plus benefits including pension scheme, annual leave, and training opportunities. We also provide a supportive and inclusive work environment, with a strong focus on career development and progression.

Contact Information:

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