Protein Expression and Purification Investigator
4 weeks ago
Role Overview
We are seeking an experienced and skilled Investigator, Protein Expression and Purification to join our team in creating innovative biopharmaceutical medicines. As a key member of our Large Molecule Discovery department, you will be responsible for the expression and characterization of antibody molecules from early Hit-Panels through to optimized engineered molecules for developability profiling.
Key Responsibilities
- Generate stable cell lines and conduct transient transfections (cell maintenance, quality control of cell culture; transfection)
- Perform protein purification using affinity and ion-exchange techniques
- Design, execute and troubleshoot workflows using Tecan-based automated liquid handling systems
- Design, perform and write up high-quality scientific experiments in a timely manner
- Influence scientific direction and execution of projects and discovery platforms in the group
Requirements
- PhD or equivalent experience in biochemical engineering, cell biology, bioprocessing or a related discipline
- Experience of stable cell line generation and transient transfection (cell maintenance, quality control of cell culture; transfection)
- Experienced in protein purification strategies
- Demonstrable ability to lead impactful projects, identify and troubleshoot problems in the execution of experiments and support other team members
- Good attention to detail in experimental setup, reporting/writing up data and verbal presentation
- Demonstrated ability to work effectively in multi-disciplinary teams and display excellent interpersonal and communication skills
Preferred Qualifications
- Expertise in the use and troubleshooting of automated LiHa (in particular Tecan and Akta systems)
- Capable of performing complex data management and data interpretation tasks/analyses
- Troubleshooting and critique of process workflows
- Track record of building collaborations internally and/or externally
- Scientific leadership skills with experience of authoring publications in peer-reviewed journals
What We Offer
We offer a competitive salary, an annual bonus based on company performance, healthcare and wellbeing programmes, pension plan membership, and shares and savings programme. We also provide a hybrid working model, empowering you to find the optimal balance between remote and in-office work.
Why GSK?
GSK is a global biopharma company with a special purpose – to unite science, technology and talent to get ahead of disease together. We prevent and treat disease with vaccines, specialty and general medicines. We focus on the science of the immune system and the use of new platform and data technologies, investing in four core therapeutic areas (infectious diseases, HIV, respiratory/immunology and oncology).
Equal Opportunities Employer
GSK is an Equal Opportunity Employer. We are open to all talent and adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to neurodiversity, race/ethnicity, colour, national origin, religion, gender, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class.
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