Protein Design and Informatics Investigator

4 weeks ago


Stevenage, Hertfordshire, United Kingdom GSK Full time
Job Description

GSK is seeking a highly skilled Investigator to join our Protein Design and Informatics team. As a key member of our Data and Predictive Sciences department, you will play a critical role in developing and integrating advanced computational methods and predictive models to accelerate the discovery of medicines.

Working closely with a diverse group of data scientists, cheminformaticians, bioinformaticians, and other experts, you will focus on developing and applying predictive models for protein design and developability engineering. Your expertise will be essential in generating, validating, and integrating sequence-/structure-based generative AIML models for the de novo design and multi-objective optimization of tool and therapeutic biologics.

As a collaborative and innovative team player, you will work closely with external groups to further develop protein engineering computational methods. Your ability to work effectively in a matrix environment and lead or contribute to team projects will be essential in driving greater impact in the face of uncertainty and change.

We offer a competitive salary, annual bonus based on company performance, healthcare and wellbeing programs, pension plan membership, and shares and savings program. Our Performance with Choice program empowers you to find the optimal balance between remote and in-office work.

Responsibilities

  • Develop and apply predictive models for protein design and developability engineering
  • Generate, validate, and integrate sequence-/structure-based generative AIML models for de novo design and multi-objective optimization
  • Collaborate with external groups to further develop protein engineering computational methods
  • Work effectively in a matrix environment and lead or contribute to team projects

Requirements

  • PhD or equivalent in Bioinformatics, Physics, Chemistry, Computer Science, Structural Biology, or related fields
  • Experience in protein structural or sequence analysis
  • Experience in one or more programming languages (e.g. Python, C/C++)
  • Experience working across scientific and technical disciplines to deliver impactful solutions

Preferred Qualifications

  • Experience developing or applying modern ML architectures for sequence- or structure-based protein design models
  • Experience predicting and analyzing protein-protein interactions and surfaces for design
  • Experience analyzing antibody repertoires for sequence- and structure-based design
  • Experience predicting structures of RNA or nucleic acid-protein complexes
  • Experience with molecular simulation techniques

Why GSK?

GSK is a global biopharma company with a special purpose – to unite science, technology and talent to get ahead of disease together. We prevent and treat disease with vaccines, specialty and general medicines. We focus on the science of the immune system and the use of new platform and data technologies, investing in four core therapeutic areas (infectious diseases, HIV, respiratory/ immunology and oncology).

We want GSK to be a place where people feel inspired, encouraged and challenged to be the best they can be. A place where they can be themselves – feeling welcome, valued, and included. Where they can keep growing and look after their wellbeing.



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