Senior Bioinformatics Specialist
7 days ago
Company Overview
Northreach is a dynamic recruitment agency that connects businesses with top talent in the Advanced Therapies sector. Our mission is to provide a seamless and personalized recruitment experience for clients and candidates, and to create a positive work environment that encourages equality, innovation, and professional growth.
Role Summary
The Senior Bioinformatics Specialist will play a pivotal role in the conceptualization, design, and implementation of innovative data analysis strategies to advance the company's ERAP1 inhibitor-driven antigen discovery pipeline. The successful candidate will analyze extensive proprietary datasets, including immunopeptidomic, transcriptomic, and genomic data, to identify ERAP1 inhibitor-dependent targets for the development of MHC class I therapeutics.
Key Responsibilities
- Contribute to developing and maintaining high-quality nextflow pipelines for processing large-scale mass spectrometry data.
- Define objectives and perform statistical analysis of data-dependent (DDA) and data-independent (DIA) immunopeptidomics assays.
- Conduct analysis of parallel reaction monitoring (PRM) peptide assays.
- Integrate antigen discovery workflows with transcriptomic and genomic data.
- Leverage external resources and databases to enhance internal workflows and improve target prioritization.
- Stay at the forefront of scientific advances in mass spectrometry-based immunopeptidomics and antigen presentation, including software and new methodologies.
- Lead and manage analytical aspects of projects, including data preparation, analysis, and visualization.
- Provide data-driven insights to inform experimental design.
- Communicate research findings to both technical and non-technical audiences, internally and externally.
Support Functions
- Act as a key member of the multidisciplinary core team to contribute to the company's overarching goals.
- Participate in strategic discussions related to bioinformatics in R&D.
- Assist in generating presentation materials for external communications.
Additional Responsibilities
- Demonstrate leadership by adhering to and promoting company policies, including data security protocols.
- Complete all required GXP/SOP training and comply with relevant SOP requirements.
- Uphold and embody the company's values.
Requirements
- PhD (or equivalent experience) in bioinformatics, immunology, computational biology, or a related field.
- In-depth knowledge of mass spectrometry-based proteomics data acquisition and processing, with familiarity in data-dependent and data-independent methods preferred.
- Strong knowledge of machine learning and/or multivariate statistical modeling.
- Proficiency in statistical programming and building statistical models.
- Expertise in R or Python programming.
- Extensive experience in large-scale bioinformatics analysis of omics data.
- Proficient in Linux OS and shell scripting.
- Experience with building and running analytical pipelines using NextFlow and Docker.
- Ability to analyze, interpret, and record findings efficiently and in compliance with standards.
- Strong communication skills, capable of conveying complex topics to diverse audiences.
- Proven success working in multidisciplinary scientific teams (desirable).
- Familiarity with cloud infrastructure (e.g., AWS) is a plus.
- Deep understanding of antigen processing (desirable).
- Prior research experience in an industrial setting (desirable).
- Knowledge of molecular biology, cell biology, or immunology (desirable).
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